发布求助
文献互助 智能选刊 最新文献

CBP/p300双抑制剂对caf -缺陷癌症中KREMEN2去抑制的疗效

IF 2 Q3 ONCOLOGY
Cancer research communications Pub Date : 2025-01-01 DOI:10.1158/2767-9764.CRC-24-0484
Mariko Sasaki, Daiki Kato, Hiroshi Yoshida, Takafumi Shimizu, Hideaki Ogiwara
{"title":"CBP/p300双抑制剂对caf -缺陷癌症中KREMEN2去抑制的疗效","authors":"Mariko Sasaki, Daiki Kato, Hiroshi Yoshida, Takafumi Shimizu, Hideaki Ogiwara","doi":"10.1158/2767-9764.CRC-24-0484","DOIUrl":null,"url":null,"abstract":"<p><strong>Significance: </strong>In this study, we clarified that the cBAF subcomplex is deficient in the SWI/SNF complex, resulting in dependency on the CBP/p300 paralog pair. Simultaneous inhibitors of the CBP/p300 paralog pair show promise for cBAF-deficient lung cancer, as well as rare cancers such as malignant rhabdoid tumors, epithelioid sarcomas, and synovial sarcomas.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"24-38"},"PeriodicalIF":2.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701801/pdf/","citationCount":"0","resultStr":"{\"title\":\"Efficacy of CBP/p300 Dual Inhibitors against Derepression of KREMEN2 in cBAF-Deficient Cancers.\",\"authors\":\"Mariko Sasaki, Daiki Kato, Hiroshi Yoshida, Takafumi Shimizu, Hideaki Ogiwara\",\"doi\":\"10.1158/2767-9764.CRC-24-0484\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Significance: </strong>In this study, we clarified that the cBAF subcomplex is deficient in the SWI/SNF complex, resulting in dependency on the CBP/p300 paralog pair. Simultaneous inhibitors of the CBP/p300 paralog pair show promise for cBAF-deficient lung cancer, as well as rare cancers such as malignant rhabdoid tumors, epithelioid sarcomas, and synovial sarcomas.</p>\",\"PeriodicalId\":72516,\"journal\":{\"name\":\"Cancer research communications\",\"volume\":\" \",\"pages\":\"24-38\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701801/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer research communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1158/2767-9764.CRC-24-0484\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer research communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1158/2767-9764.CRC-24-0484","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

SWI/SNF染色质重塑复合体分为三个亚复合体：cBAF、PBAF和ncBAF。SWI/SNF复合体的组成基因（例如SMARCB1、SMARCA4、SMARCA2和SS18）在各种癌症中经常存在遗传异常。之前，我们发现组蛋白乙酰转移酶CBP/p300双抑制剂可能是治疗smarcb1缺陷癌症的有希望的方法。研究表明，使用CBP/p300双抑制剂治疗cbaf缺陷癌症（如SMARCA4/ smarca2缺陷和SS18-SSX融合癌症）可导致合成致死。鉴于对CBP/p300双抑制剂的敏感性以及它们与含有每个亚基的SWI/SNF亚复合物的共性，CBP/p300双抑制剂可能是治疗包含整个cBAF亚复合物中成分基因异常的癌症的有希望的治疗方法。由于SMARCA4/ smarca2缺陷和SS18-SSX融合的癌细胞依赖于由于SMARCA4/ smarca2缺陷和SS18-SSX融合而导致的KREMEN2转录上调，我们阐明了通过同时抑制CBP/p300来抑制KREMEN2的表达可以诱导合成致死。此外，同时抑制CBP/p300可导致KREMEN2转录下调，随后通过KREMEN1诱导细胞凋亡。此外，使用CBP/p300双抑制剂治疗可抑制源自SMARCA4/ smarca2缺陷和SS18-SSX融合癌细胞的异种移植物的生长，这是由于抑制KREMEN2和诱导凋亡。因此，CBP/p300双抑制剂有望治疗完全缺乏cBAF复合物的SMARCA4/ smarca2缺陷肺癌和SS18-SSX融合滑膜肉瘤。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
分享
查看原文 本刊更多论文
Efficacy of CBP/p300 Dual Inhibitors against Derepression of KREMEN2 in cBAF-Deficient Cancers.

Significance: In this study, we clarified that the cBAF subcomplex is deficient in the SWI/SNF complex, resulting in dependency on the CBP/p300 paralog pair. Simultaneous inhibitors of the CBP/p300 paralog pair show promise for cBAF-deficient lung cancer, as well as rare cancers such as malignant rhabdoid tumors, epithelioid sarcomas, and synovial sarcomas.

求助全文
通过发布文献求助，成功后即可免费获取论文全文。 去求助
来源期刊
Cancer research communications
Cancer research communications
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信