唾液腺嗜瘤细胞瘤。系统评价。

IF 3.2 Q2 PATHOLOGY
Peraza Labrador Alberto, Shrestha Ashim, Koch Megan, Zhang Wei, Gonzalez Nestor, Zhou Matthew, Mamani Dayana, Villacis Marcelo, Wright John
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引用次数: 0

摘要

背景:嗜酸细胞瘤是一种原发性良性上皮性肿瘤,占唾液肿瘤的不到2%,复发率低。方法:系统回顾记录的病例报告和病例系列的嗜瘤细胞瘤提出。从不同的数据库中进行搜索,以确定1956年至2024年的文章。变量包括性别、年龄、症状、诊断前持续时间、腺体类型、组织学特征、特殊或免疫组织化学评价、治疗、随访、复发以及与疾病或综合征的关系。结果:147例患者中,女性占53.1%,男性占46.9%。平均年龄58.7岁,平均体型2.3 cm。最常见的临床表现为肿胀(92.6%),66.7%无症状。腮腺是最常见的腺体,占66%,下颌骨腺占23.3%,次要唾液腺以磷钨酸-苏木精(PTAH)为最常见的特殊染色(36.7%),其次是周期性酸-希夫(PAS)合并和不合并淀粉酶(26.6%)。切除活检是最常见的治疗方法(38.1%),其次是腮腺浅表切除术(32.7%)。平均随访34.7个月。双侧癌细胞瘤发生率为4.8%,男女比例为6:1。复发率为2.7%,与BHD综合征相关的为8.2%。结论:唾液嗜酸细胞瘤是一种罕见的上皮性肿瘤,临床表现无特异性。细胞学检查可怀疑诊断,组织学检查可确诊。病变有一个惰性的临床过程,大多数报告的病例没有复发。双侧肿瘤细胞瘤与女性之间似乎存在关联,与BHD之间的关联虽低,但很有趣。总之,本综述有助于更好地突出这种罕见良性肿瘤的特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Salivary Gland Oncocytomas. A Systematic Review.

Background: Oncocytoma is a primary benign epithelial neoplasm comprising less than 2% of salivary tumors with a low recurrence rate.

Methods: A systematic review of documented case reports and case series of oncocytomas is presented. Searches from different databases were performed to identify articles from 1956 to 2024. The variables included were gender, age, symptoms, duration time before diagnosis, type of gland, histological features, special or immunohistochemical evaluation, treatment, follow-up, recurrence, and relation with a medical condition or syndrome.

Results: Of the 147 cases reported, 53.1% affected females, and 46.9% were in males. The average age was 58.7 years, and the mean size was 2.3 cm. The most common clinical presentation was swelling (92.6%) and 66.7% were asymptomatic. The parotid was the most commonly affected gland with 66% of cases, the submandibular gland with 23.3%, and the minor salivary glands with Phosphotungstic acid-hematoxylin (PTAH) was the most common special stain used in 36.7%, followed by a combination with Periodic acid-Schiff (PAS) with and without diastase in 26.6%. Excisional biopsy was the most common treatment in 38.1% followed by superficial parotidectomy in 32.7%. Follow-up was 34.7 months on average. Bilateral oncocytomas were found in 4.8% with a 6 to 1 female-male proportion. Recurrence was found in 2.7% and association with Birt-Hogg-Dube (BHD) syndrome was 8.2%.

Conclusion: Salivary oncocytoma is a rare epithelial neoplasm with nonspecific clinical presentations. Diagnosis can be suspected on cytology and confirmed by histologic examination. The lesion has an indolent clinical course and most of the reported cases did not recur. There seems to be an association between bilateral oncocytomas and females and a low but interesting association with BHD. Overall, this review serves to better highlight the features of this rare benign neoplasm.

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来源期刊
CiteScore
5.70
自引率
9.50%
发文量
99
期刊介绍: Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.
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