{"title":"唾液腺嗜瘤细胞瘤。系统评价。","authors":"Peraza Labrador Alberto, Shrestha Ashim, Koch Megan, Zhang Wei, Gonzalez Nestor, Zhou Matthew, Mamani Dayana, Villacis Marcelo, Wright John","doi":"10.1007/s12105-024-01730-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Oncocytoma is a primary benign epithelial neoplasm comprising less than 2% of salivary tumors with a low recurrence rate.</p><p><strong>Methods: </strong>A systematic review of documented case reports and case series of oncocytomas is presented. Searches from different databases were performed to identify articles from 1956 to 2024. The variables included were gender, age, symptoms, duration time before diagnosis, type of gland, histological features, special or immunohistochemical evaluation, treatment, follow-up, recurrence, and relation with a medical condition or syndrome.</p><p><strong>Results: </strong>Of the 147 cases reported, 53.1% affected females, and 46.9% were in males. The average age was 58.7 years, and the mean size was 2.3 cm. The most common clinical presentation was swelling (92.6%) and 66.7% were asymptomatic. The parotid was the most commonly affected gland with 66% of cases, the submandibular gland with 23.3%, and the minor salivary glands with Phosphotungstic acid-hematoxylin (PTAH) was the most common special stain used in 36.7%, followed by a combination with Periodic acid-Schiff (PAS) with and without diastase in 26.6%. Excisional biopsy was the most common treatment in 38.1% followed by superficial parotidectomy in 32.7%. Follow-up was 34.7 months on average. Bilateral oncocytomas were found in 4.8% with a 6 to 1 female-male proportion. Recurrence was found in 2.7% and association with Birt-Hogg-Dube (BHD) syndrome was 8.2%.</p><p><strong>Conclusion: </strong>Salivary oncocytoma is a rare epithelial neoplasm with nonspecific clinical presentations. Diagnosis can be suspected on cytology and confirmed by histologic examination. The lesion has an indolent clinical course and most of the reported cases did not recur. There seems to be an association between bilateral oncocytomas and females and a low but interesting association with BHD. Overall, this review serves to better highlight the features of this rare benign neoplasm.</p>","PeriodicalId":47972,"journal":{"name":"Head & Neck Pathology","volume":"18 1","pages":"126"},"PeriodicalIF":3.2000,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608208/pdf/","citationCount":"0","resultStr":"{\"title\":\"Salivary Gland Oncocytomas. A Systematic Review.\",\"authors\":\"Peraza Labrador Alberto, Shrestha Ashim, Koch Megan, Zhang Wei, Gonzalez Nestor, Zhou Matthew, Mamani Dayana, Villacis Marcelo, Wright John\",\"doi\":\"10.1007/s12105-024-01730-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Oncocytoma is a primary benign epithelial neoplasm comprising less than 2% of salivary tumors with a low recurrence rate.</p><p><strong>Methods: </strong>A systematic review of documented case reports and case series of oncocytomas is presented. Searches from different databases were performed to identify articles from 1956 to 2024. The variables included were gender, age, symptoms, duration time before diagnosis, type of gland, histological features, special or immunohistochemical evaluation, treatment, follow-up, recurrence, and relation with a medical condition or syndrome.</p><p><strong>Results: </strong>Of the 147 cases reported, 53.1% affected females, and 46.9% were in males. The average age was 58.7 years, and the mean size was 2.3 cm. The most common clinical presentation was swelling (92.6%) and 66.7% were asymptomatic. The parotid was the most commonly affected gland with 66% of cases, the submandibular gland with 23.3%, and the minor salivary glands with Phosphotungstic acid-hematoxylin (PTAH) was the most common special stain used in 36.7%, followed by a combination with Periodic acid-Schiff (PAS) with and without diastase in 26.6%. Excisional biopsy was the most common treatment in 38.1% followed by superficial parotidectomy in 32.7%. Follow-up was 34.7 months on average. Bilateral oncocytomas were found in 4.8% with a 6 to 1 female-male proportion. Recurrence was found in 2.7% and association with Birt-Hogg-Dube (BHD) syndrome was 8.2%.</p><p><strong>Conclusion: </strong>Salivary oncocytoma is a rare epithelial neoplasm with nonspecific clinical presentations. Diagnosis can be suspected on cytology and confirmed by histologic examination. The lesion has an indolent clinical course and most of the reported cases did not recur. There seems to be an association between bilateral oncocytomas and females and a low but interesting association with BHD. Overall, this review serves to better highlight the features of this rare benign neoplasm.</p>\",\"PeriodicalId\":47972,\"journal\":{\"name\":\"Head & Neck Pathology\",\"volume\":\"18 1\",\"pages\":\"126\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-11-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608208/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Head & Neck Pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s12105-024-01730-6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Head & Neck Pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12105-024-01730-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PATHOLOGY","Score":null,"Total":0}
Background: Oncocytoma is a primary benign epithelial neoplasm comprising less than 2% of salivary tumors with a low recurrence rate.
Methods: A systematic review of documented case reports and case series of oncocytomas is presented. Searches from different databases were performed to identify articles from 1956 to 2024. The variables included were gender, age, symptoms, duration time before diagnosis, type of gland, histological features, special or immunohistochemical evaluation, treatment, follow-up, recurrence, and relation with a medical condition or syndrome.
Results: Of the 147 cases reported, 53.1% affected females, and 46.9% were in males. The average age was 58.7 years, and the mean size was 2.3 cm. The most common clinical presentation was swelling (92.6%) and 66.7% were asymptomatic. The parotid was the most commonly affected gland with 66% of cases, the submandibular gland with 23.3%, and the minor salivary glands with Phosphotungstic acid-hematoxylin (PTAH) was the most common special stain used in 36.7%, followed by a combination with Periodic acid-Schiff (PAS) with and without diastase in 26.6%. Excisional biopsy was the most common treatment in 38.1% followed by superficial parotidectomy in 32.7%. Follow-up was 34.7 months on average. Bilateral oncocytomas were found in 4.8% with a 6 to 1 female-male proportion. Recurrence was found in 2.7% and association with Birt-Hogg-Dube (BHD) syndrome was 8.2%.
Conclusion: Salivary oncocytoma is a rare epithelial neoplasm with nonspecific clinical presentations. Diagnosis can be suspected on cytology and confirmed by histologic examination. The lesion has an indolent clinical course and most of the reported cases did not recur. There seems to be an association between bilateral oncocytomas and females and a low but interesting association with BHD. Overall, this review serves to better highlight the features of this rare benign neoplasm.
期刊介绍:
Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck.
The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field.
Single-blind peer review
The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.