肿瘤浸润淋巴细胞在胃癌预后中的作用：一项系统综述和荟萃分析。

IF 2.6 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinics and research in hepatology and gastroenterology Pub Date : 2025-01-01 DOI:10.1016/j.clinre.2024.102510

Xiaoqing Cao , Yurou Kang , Ping Tai, Pei Zhang, Xin Lin, Fei Xu, Zhenlin Nie, Bangshun He

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引用次数: 0

摘要

背景：分析胃癌（GC）患者肿瘤浸润淋巴细胞（tumor-浸润淋巴细胞，TILs）亚型及浸润部位与预后的关系。方法：通过系统检索和严格筛选，收集研究信息，提取风险比（HR）和95%置信区间（CI），对无病生存期（DFS）和总生存期（OS）进行合并分析，获得符合条件的文献。结果：CD4+ TILs越高，OS越好（HR=0.79, 95%CI: 0.66 ~ 0.94， P=0.009），肿瘤中心和浸润边缘的结果相似。较高的CD8+ TILs延长DFS （HR=0.69, 95%CI: 0.51 ~ 0.95， P=0.02）和OS (HR=0.96, 95%CI: 0.94 ~ 0.99， P=0.006)；肿瘤中心组和浸润边缘组OS阳性。总体分析和亚组分析均未显示FOXP3+ TILs水平与预后相关(DFS: HR=0.89, 95%CI: 0.66-1.19， P=0.42；Os: hr =0.98, 95%ci: 0.85-1.13, p =0.75)。综合结果显示，较高的CD3+ TILs与较好的DFS相关（HR=0.69, 95%CI: 0.56 ~ 0.84， P=0.0003），但与OS无关（HR=1.00, 95%CI: 0.99 ~ 1.01， P=0.48）。结论：高浸润的CD3+、CD4+、CD8+ T细胞延长了胃癌患者的生存期，FOXP3+亚群与预后无关。肿瘤中心组和浸润边缘组CD4+、CD8+浸润水平与OS呈正相关。

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Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis

Background

To analyze the relationship between tumor-infiltrating lymphocytes (TILs) subtypes and infiltration locations and the prognosis of gastric cancer (GC) patients.

Methods

Eligible articles were obtained through systematic retrieval and rigorous screening, collecting study information and extracting hazard ratio (HR), 95 % confidence interval (CI) for pooled analyses of disease-free survival (DFS) and overall survival (OS).

Results

Higher CD4⁺ TILs were correlated with favorable OS (HR=0.79, 95 %CI: 0.66–0.94, P = 0.009), the similar results were observed in tumor center and in infiltration margin. Higher CD8⁺ TILs prolonged DFS (HR=0.69, 95 %CI: 0.51–0.95, P = 0.02) and OS (HR=0.96, 95 %CI: 0.94–0.99, P = 0.006); For OS, tumor center and infiltration margin groups showed positive results. Neither the overall analysis nor the subgroup analyses indicated that the level of FOXP3⁺ TILs was associated with prognosis (DFS: HR=0.89, 95 %CI: 0.66–1.19, P = 0.42; OS: HR=0.98, 95 %CI: 0.85–1.13, P = 0.75). Pooled results revealed that higher CD3⁺ TILs were correlated with favorable DFS (HR=0.69, 95 %CI: 0.56–0.84, P = 0.0003) but not OS (HR=1.00, 95 %CI: 0.99–1.01, P = 0.48).

Conclusions

High infiltrating CD3⁺, CD4⁺, CD8⁺ T cells prolong survival, and FOXP3⁺ subset is not related to prognosis in GC. For CD4⁺ and CD8⁺, positive correlations between the infiltration level and OS were present in tumor center and infiltration margin groups.

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来源期刊

Clinics and research in hepatology and gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.30

自引率

3.70%

发文量

198

审稿时长

42 days

期刊介绍： Clinics and Research in Hepatology and Gastroenterology publishes high-quality original research papers in the field of hepatology and gastroenterology. The editors put the accent on rapid communication of new research and clinical developments and so called "hot topic" issues. Following a clear Editorial line, besides original articles and case reports, each issue features editorials, commentaries and reviews. The journal encourages research and discussion between all those involved in the specialty on an international level. All articles are peer reviewed by international experts, the articles in press are online and indexed in the international databases (Current Contents, Pubmed, Scopus, Science Direct). Clinics and Research in Hepatology and Gastroenterology is a subscription journal (with optional open access), which allows you to publish your research without any cost to you (unless you proactively chose the open access option). Your article will be available to all researchers around the globe whose institution has a subscription to the journal.