神经干细胞移植治疗慢性胸脊髓损伤的长期临床和安全性研究

IF 11.7 1区医学 Q1 CELL BIOLOGY

Cell Reports Medicine Pub Date : 2024-12-17 Epub Date: 2024-12-02 DOI:10.1016/j.xcrm.2024.101841

Joel R Martin, Daniel Cleary, Mickey E Abraham, Michelle Mendoza, Betty Cabrera, Catriona Jamieson, Martin Marsala, Joseph D Ciacci

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引用次数: 0

摘要

我们报告了神经干细胞移植治疗慢性脊髓损伤的一期研究的长期结果。该试验已在ClinicalTrials.gov注册为NCT01772810。该试验的主要结果是测试人脊髓源性神经干细胞（NSI-566）移植治疗4例胸2至胸12脊髓损伤的慢性脊髓损伤的可行性和安全性。在这里，我们报告了所有四名受试者对干细胞植入手术的耐受性良好，其中两名受试者在移植后五年内有持久的肌电图-可量化的神经系统改善证据，以及神经运动和感觉评分的增加。

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Long-term clinical and safety outcomes from a single-site phase 1 study of neural stem cell transplantation for chronic thoracic spinal cord injury.

We report the long-term results for a phase 1 study of neural stem cell transplantation for chronic spinal cord injury. The trial was registered on ClinicalTrials.gov as NCT01772810. The primary outcome of the trial was to test the feasibility and safety of human spinal cord-derived neural stem cell (NSI-566) transplantation for the treatment of chronic spinal cord injury in four subjects with thoracic two to thoracic twelve spinal cord injury. Here, we report that all four subjects tolerated the stem cell implantation procedure well, and two subjects had durable electromyography-quantifiable evidence of neurological improvement as well as increased neurological motor and sensory scores at five years post-transplantation.

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来源期刊

Cell Reports Medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

15.00

自引率

1.40%

发文量

231

审稿时长

40 days

期刊介绍： Cell Reports Medicine is an esteemed open-access journal by Cell Press that publishes groundbreaking research in translational and clinical biomedical sciences, influencing human health and medicine. Our journal ensures wide visibility and accessibility, reaching scientists and clinicians across various medical disciplines. We publish original research that spans from intriguing human biology concepts to all aspects of clinical work. We encourage submissions that introduce innovative ideas, forging new paths in clinical research and practice. We also welcome studies that provide vital information, enhancing our understanding of current standards of care in diagnosis, treatment, and prognosis. This encompasses translational studies, clinical trials (including long-term follow-ups), genomics, biomarker discovery, and technological advancements that contribute to diagnostics, treatment, and healthcare. Additionally, studies based on vertebrate model organisms are within the scope of the journal, as long as they directly relate to human health and disease.