年龄相关克隆造血和HIV感染与老年结局相关：ARCHIVE研究

IF 11.7 1区医学 Q1 CELL BIOLOGY

Cell Reports Medicine Pub Date : 2024-12-17 Epub Date: 2024-12-02 DOI:10.1016/j.xcrm.2024.101835

Win Min Han, Hossain M S Sazzad, Mark Bloch, David A Baker, Norman Roth, Ellen Bowden-Reid, Don E Smith, Jennifer F Hoy, Ian Woolley, Robert Finlayson, David J Templeton, Gail V Matthews, Jane Costello, Mark A Dawson, Sarah-Jane Dawson, Mark N Polizzotto, Kathy Petoumenos, Paul Yeh, Nila J Dharan

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引用次数: 0

摘要

虽然HIV感染和克隆造血（CH）与炎症失调和衰老相关合并症的风险增加有关，但它们与临床老年综合征的关系尚未得到很好的定义。在HIV评估队列（ARCHIVE）研究（NCT04641013）中的年龄相关克隆造血中，我们测量了HIV、CH和老年综合征之间的关联。在345名参与者中（176名携带艾滋病毒，169名没有艾滋病毒），23%的人至少有一种与CH相关的突变：27%携带艾滋病毒，18%没有艾滋病毒（p = 0.048）。在调整分析中，HIV感染与表型年龄加速增加独立相关（系数1.73,95%可信区间[CI] 0.3, 3.16）， CH与体弱独立相关(相对于体弱前/健壮；优势比2.38,95% CI 1.01, 5.67)和生活质量降低（系数-2.18,95% CI -3.92, -0.44）。我们的研究结果表明，HIV与生物年龄的增加有关，CH可能被用作不良老年结局的生物标志物。

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Age-related clonal hematopoiesis and HIV infection are associated with geriatric outcomes: The ARCHIVE study.

While HIV infection and clonal hematopoiesis (CH) have been linked with inflammatory dysregulation and an increased risk of aging-related comorbidities, their relationship with clinical geriatric syndromes has not been well defined. In the Age-related Clonal Haematopoiesis in an HIV Evaluation Cohort (ARCHIVE) study (NCT04641013), we measure associations between HIV and CH and geriatric syndromes. Of 345 participants (176 with HIV and 169 without HIV), 23% had at least one mutation associated with CH: 27% with HIV and 18% without HIV (p = 0.048). In adjusted analyses, HIV infection is independently associated with increased phenotypic age acceleration (coefficient 1.73, 95% confidence interval [CI] 0.3, 3.16) and CH is independently associated with being frail (vs. pre-frail/robust; odds ratio 2.38, 95% CI 1.01, 5.67) and with having reduced quality of life (coefficient -2.18, 95% CI -3.92, -0.44). Our findings suggest that HIV is associated with increased biological age and that CH may be used as a biomarker for adverse geriatric outcomes.

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来源期刊

Cell Reports Medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

15.00

自引率

1.40%

发文量

231

审稿时长

40 days

期刊介绍： Cell Reports Medicine is an esteemed open-access journal by Cell Press that publishes groundbreaking research in translational and clinical biomedical sciences, influencing human health and medicine. Our journal ensures wide visibility and accessibility, reaching scientists and clinicians across various medical disciplines. We publish original research that spans from intriguing human biology concepts to all aspects of clinical work. We encourage submissions that introduce innovative ideas, forging new paths in clinical research and practice. We also welcome studies that provide vital information, enhancing our understanding of current standards of care in diagnosis, treatment, and prognosis. This encompasses translational studies, clinical trials (including long-term follow-ups), genomics, biomarker discovery, and technological advancements that contribute to diagnostics, treatment, and healthcare. Additionally, studies based on vertebrate model organisms are within the scope of the journal, as long as they directly relate to human health and disease.