希夫碱-铂钌配合物及其抗阿尔茨海默病特性。

IF 3.8 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Inorganic Biochemistry Pub Date : 2024-11-30 DOI:10.1016/j.jinorgbio.2024.112790

Salih Günnaz , Esma Yildiz , Ayça Tunçel Oral , Fatma Yurt , Arzum Erdem , Sevil Irişli

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引用次数: 0

摘要

本研究探讨了含二亚胺结构希夫碱的铂和钌配合物对阿尔茨海默病的影响。合成了希夫碱(N1E,N2E)-N1， n2 -二（异喹啉-4-基亚甲基）苯-1,2-二胺(I)和新型Pt（II）和Ru（II）配合物（Ia和Ib），并利用FTIR、NMR （1H, 13C）、质谱和元素分析对其进行了表征。它们抑制β淀粉样蛋白（a - β1-42）聚集的能力是用SH-SY5Y细胞系体外测定的。荧光光谱研究了Aβ1-42与配合物的早期聚集动力学和剂量依赖性。透射电子显微镜证实了这一结果。基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）和1H NMR谱分析了与Aβ1-16的相互作用。方波伏安法监测了与a - β1-42的相互作用。合成的配合物在低摩尔比下具有抑制淀粉样蛋白聚集的活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Schiff Base–platinum and ruthenium complexes and anti-Alzheimer properties

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Schiff Base–platinum and ruthenium complexes and anti-Alzheimer properties

This study investigates the effects of Pt and Ru complexes containing a Schiff base with a diimine structure on Alzheimer's disease. The Schiff base (N1E,N2E)-N1,N2-bis(isoquinolin-4-ylmethylene)benzene-1,2-diamine (I) and the novel Pt(II) and Ru(II) complexes (Ia and Ib) were synthesized and characterized using FTIR, NMR (¹H, ¹³C), mass spectrometry, and elemental analyses. Their ability to inhibit amyloid beta (Aβ_1–42) aggregation was determined in vitro using the SH-SY5Y cell line. Fluorescence spectroscopy investigated the early aggregation kinetics and dose-dependent characteristics of Aβ₁_–₄₂ with the complexes. Transmission electron microscopy confirmed the results. Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI–TOF MS) and ¹H NMR spectroscopy examined the interaction with Aβ₁_–₁₆. Electrochemical analysis using square wave voltammetry monitored the interaction with Aβ₁_–₄₂. The synthesized complexes were active in inhibiting amyloid aggregation at a low molar ratio.

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来源期刊

Journal of Inorganic Biochemistry 生物-生化与分子生物学

CiteScore

7.00

自引率

10.30%

发文量

336

审稿时长

41 days

期刊介绍： The Journal of Inorganic Biochemistry is an established international forum for research in all aspects of Biological Inorganic Chemistry. Original papers of a high scientific level are published in the form of Articles (full length papers), Short Communications, Focused Reviews and Bioinorganic Methods. Topics include: the chemistry, structure and function of metalloenzymes; the interaction of inorganic ions and molecules with proteins and nucleic acids; the synthesis and properties of coordination complexes of biological interest including both structural and functional model systems; the function of metal- containing systems in the regulation of gene expression; the role of metals in medicine; the application of spectroscopic methods to determine the structure of metallobiomolecules; the preparation and characterization of metal-based biomaterials; and related systems. The emphasis of the Journal is on the structure and mechanism of action of metallobiomolecules.