非整倍体癌症的靶向RNA和蛋白质转换

IF 29.7 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2024-12-02 DOI:10.1158/2159-8290.cd-24-1350

Samuel F. Bakhoum

引用次数: 0

摘要

摘要：非整倍体，染色体数目的不平衡，是具有染色体不稳定性的人类癌症的一个标志，它仍然是一个主要的治疗挑战。在这一期中，Ippolito和他的同事发现RNA和蛋白质转换是非整倍体癌症的靶向治疗脆弱性。参见相关文章，由Ippolito等人，p. 2532

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Targeting RNA and Protein Turnover in Aneuploid Cancers

Summary:Aneuploidy, an imbalance in chromosome number, is a hallmark of human cancers with chromosomal instability, and it remains a major therapeutic challenge. In this issue, Ippolito and colleagues identify RNA and protein turnover as targetable therapeutic vulnerabilities in aneuploid cancers.See related article by Ippolito et al., p. 2532

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.