复合GLP - 1和双重GIP/GLP - 1受体激动剂：美国糖尿病协会声明

IF 14.8 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes Care Pub Date : 2024-12-02 DOI:10.2337/dci24-0091

Joshua J. Neumiller, Mandeep Bajaj, Raveendhara R. Bannuru, Rozalina G. McCoy, Elizabeth J. Pekas, Alissa R. Segal, Nuha A. ElSayed

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引用次数: 0

摘要

胰高血糖素样肽1受体激动剂（GLP-1 RA）和双葡萄糖依赖性胰岛素多肽（GIP）和GLP-1 RA （GIP/GLP-1 RA）类别在过去几年中用于治疗2型糖尿病和肥胖症的使用大幅增加。对这些药物治疗的需求增加导致GLP-1 RA和双GIP/GLP-1 RA药物的暂时产品短缺。这些短缺在一定程度上导致实体生产和销售绕过监管措施的复方制剂，引起了对安全、质量和功效的担忧。即使短缺得到解决，复合GLP-1 RA和GIP/GLP-1 RA产品继续大量销售给糖尿病和肥胖症患者。美国糖尿病协会的这一声明的目的是指导医疗保健专业人员和糖尿病和/或肥胖患者在这些药物不可用的情况下促进最佳护理和药物使用安全。

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Compounded GLP 1 and Dual GIP/GLP 1 Receptor Agonists: A Statement from the American Diabetes Association

The use of glucagon-like peptide 1 receptor agonist (GLP-1 RA) and dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 RA (GIP/GLP-1 RA) classes has increased substantially over the past several years for treating type 2 diabetes and obesity. Increased demand for these pharmacotherapies has resulted in temporary product shortages for both GLP-1 RA and dual GIP/GLP-1 RA medications. These shortages, in part, have led to entities producing and marketing compounded formulations that bypass regulatory measures, raising safety, quality, and efficacy concerns. Even as shortages resolve, compounded GLP-1 RA and GIP/GLP-1 RA products continue to be heavily marketed to people with diabetes and obesity. The purpose of this statement by the American Diabetes Association is to guide health care professionals and people with diabetes and/or obesity in these circumstances of medication unavailability to promote optimal care and medication use safety.

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来源期刊

Diabetes Care 医学-内分泌学与代谢

CiteScore

27.80

自引率

4.90%

发文量

449

审稿时长

1 months

期刊介绍： The journal's overarching mission can be captured by the simple word "Care," reflecting its commitment to enhancing patient well-being. Diabetes Care aims to support better patient care by addressing the comprehensive needs of healthcare professionals dedicated to managing diabetes. Diabetes Care serves as a valuable resource for healthcare practitioners, aiming to advance knowledge, foster research, and improve diabetes management. The journal publishes original research across various categories, including Clinical Care, Education, Nutrition, Psychosocial Research, Epidemiology, Health Services Research, Emerging Treatments and Technologies, Pathophysiology, Complications, and Cardiovascular and Metabolic Risk. Additionally, Diabetes Care features ADA statements, consensus reports, review articles, letters to the editor, and health/medical news, appealing to a diverse audience of physicians, researchers, psychologists, educators, and other healthcare professionals.