评估血管紧张素转换酶插入/缺失、α内缩蛋白（ADD1） G460W和IL-10基因多态性，并确定特发性突发性感音神经性听力损失的预后影响

IF 1.4 Q2 OTORHINOLARYNGOLOGY

Journal of Otology Pub Date : 2024-04-01 DOI:10.1016/j.joto.2024.03.002

Vural Akın , Mehmet Emre Sivrice , Kuyaş Hekimler Öztürk , Hasan Yasan , Mustafa Tüz , Erdoğan Okur , Yusuf Çağdaş Kumbul

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引用次数: 0

摘要

目的本研究旨在探讨血管紧张素转换酶（ACE）插入/缺失、α -内合蛋白和白介素-10 （IL-10）基因多态性（GPs）与特发性突发性感音神经性听力损失（ISSNHL）风险及其潜在的预后影响。方法研究组70例，对照组50例。通过竞争性等位基因特异性聚合酶链反应分析静脉血样本中相关的gp。年龄、性别、受累侧、耳鸣、眩晕症状状态、症状发作至入院天数、入院时和治疗后纯音听力学结果均被纳入研究。数据进行统计学比较。结果ISSNHL患者ACE插入/缺失GP基因D等位基因出现频率明显高于对照组（p = 0.032）。II基因型与ISSNHL风险降低相关（p = 0.036）。具有TT基因型（p = 0.027）和IL-10 GP的T等位基因（p = 0.035）的患者的听力损失明显高于没有该等位基因的患者。重度听力损失是不良预后因素（p = 0.008）。结论ACE插入/缺失GP基因D等位基因可能参与ISSNHL的发病机制。由于该等位基因与闭塞性血管病变相关，缺血被认为是ISSNHL发病的一个共同途径。

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Evaluation of angiotensin converting enzyme insertion/deletion, alpha adducin (ADD1) G460W, and IL-10 gene polymorphisms, and determination of prognostic effects in idiopathic sudden sensorineural hearing loss

Objective

The aim of this study was to examine angiotensin converting enzyme (ACE) insertion/deletion, alpha adducin, and interleukin-10 (IL-10) gene polymorphisms (GPs) in terms of both idiopathic sudden sensorineural hearing loss (ISSNHL) risk and their potential prognostic effects.

Methods

The study group consisted of 70 patients and the control group consisted of 50 patients. Venous blood samples were analyzed for relevant GPs via kompetitive allele-specific polymerase chain reaction. Age, sex, affected side, tinnitus, and vertiginous symptom status, number of days between symptom onset and hospital admission, pure tone audiometry results at admission and after treatment were included in the study. Data were compared statistically.

Results

The D allele of ACE insertion/deletion GP was significantly more frequent in patients with ISSNHL than in the control group (p = 0.032). II genotype was associated with a reduced risk of ISSNHL (p = 0.036). The amount of hearing loss was significantly higher in patients with the TT genotype (p = 0.027) and T allele of the IL-10 GP (p = 0.035) than in the patients without this allele. Severe hearing loss was a poor prognostic factor (p = 0.008).

Conclusions

The D allele of ACE insertion/deletion GP may be involved in the ISSNHL etiology. Due to the association of this allele with occlusive vascular pathologies, ischemia is believed to be a common pathway in the etiopathogenesis of ISSNHL.

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来源期刊

Journal of Otology Medicine-Otorhinolaryngology

CiteScore

2.70

自引率

0.00%

发文量

461

审稿时长

18 days

期刊介绍： Journal of Otology is an open access, peer-reviewed journal that publishes research findings from disciplines related to both clinical and basic science aspects of auditory and vestibular system and diseases of the ear. This journal welcomes submissions describing original experimental research that may improve our understanding of the mechanisms underlying problems of basic or clinical significance and treatment of patients with disorders of the auditory and vestibular systems. In addition to original papers the journal also offers invited review articles on current topics written by leading experts in the field. The journal is of primary importance for all scientists and practitioners interested in audiology, otology and neurotology, auditory neurosciences and related disciplines. Journal of Otology welcomes contributions from scholars in all countries and regions across the world.