一种新型水溶性高选择性铁（III）荧光化学传感器的合成

IF 4 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Structure Pub Date : 2024-11-22 DOI:10.1016/j.molstruc.2024.140753

David Gallardo-Rosas , Luis D. Rosales-Vázquez , José M. Guevara-Vela , César I. Sandoval-Chávez , Alejandro Dorazco-González , Tomás Rocha-Rinza , José G. López-Cortés , M. Carmen Ortega-Alfaro

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引用次数: 0

摘要

本文描述了一种基于4h -喹啉-4-酮（4b）的新型Fe（III）选择性荧光化学传感器的设计、合成和研究。该化学传感器对微摩尔浓度范围内的水混合物以及其他常见干扰金属离子的存在具有很高的灵敏度和选择性，在DMSO/水1:1的二元溶剂中具有13.15 μM的检出限（LOD），是一种很有前途的检测Fe（III）的工具。此外，该化学受体在0 ~ 12 μM Fe（III）范围内表现出线性和稳定的荧光响应，具有高亲和力（3.13 × 106 M-2），可用于该金属离子的定量测定。这些结果可以设想在诊断各种铁相关疾病中检测铁（III）的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of a new water-soluble highly Fe(III)-selective fluorescent chemosensor based on 4H-quinolizin-4-one

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Synthesis of a new water-soluble highly Fe(III)-selective fluorescent chemosensor based on 4H-quinolizin-4-one

We describe the design, synthesis and studies of a new Fe(III)-selective fluorescent chemosensor in aqueous media based on a 4H-quinolizin-4-one (4b). This chemosensor exhibits high sensitivity and selectivity for the detection of Fe(III) in aqueous mixtures in the micromolar concentration range as well as in the presence of other common interfering metal ions, making it a promising tool for the detection of Fe(III) with a limit of detection (LOD) of 13.15 μM in binary solvents DMSO/water, 1:1. Furthermore, this chemoreceptor exhibits a linear and stable fluorescent response over a range of 0 to 12 μM of Fe(III), with high affinity (3.13 × 10⁶ M^-2), which allows the quantitative determination of this metal ion. These results allow to envisage potential applications for the detection of Fe(III) in the diagnosis various of ferric-related diseases.

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来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

期刊介绍： The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including: • Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.) • Chemical intermediates • Molecules in excited states • Biological molecules • Polymers. The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example: • Infrared spectroscopy (mid, far, near) • Raman spectroscopy and non-linear Raman methods (CARS, etc.) • Electronic absorption spectroscopy • Optical rotatory dispersion and circular dichroism • Fluorescence and phosphorescence techniques • Electron spectroscopies (PES, XPS), EXAFS, etc. • Microwave spectroscopy • Electron diffraction • NMR and ESR spectroscopies • Mössbauer spectroscopy • X-ray crystallography • Charge Density Analyses • Computational Studies (supplementing experimental methods) We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.