围手术期非甾体类抗炎药：目前的争议和关注。

IF 9.1 1区医学 Q1 ANESTHESIOLOGY

British journal of anaesthesia Pub Date : 2025-02-01 DOI:10.1016/j.bja.2024.10.018

Girish P. Joshi , Henrik Kehlet , Dileep N. Lobo

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引用次数: 0

摘要

非甾体抗炎药（NSAIDs）和环氧化酶(COX)-2特异性抑制剂提供了显著的镇痛和阿片类药物节约效益。然而，由于担心潜在的不良反应，通常避免使用这些镇痛药。与非甾体抗炎药相关的不良反应的证据是相互矛盾的，而且质量很差，这些镇痛药比所暗示的更安全。因此，必须常规使用非甾体抗炎药或cox -2特异性抑制剂，除非有充分的禁忌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nonsteroidal anti-inflammatory drugs in the perioperative period: current controversies and concerns

Nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase (COX)-2-specific inhibitors provide significant analgesic and opioid-sparing benefits. However, these analgesics are commonly avoided owing to concerns of potential adverse effects. The evidence for NSAID-related adverse effects is conflicting and of poor quality, and these analgesics are safer than what has been implied. Thus, it is imperative that NSAIDs or COX-2-specific inhibitors are administered routinely unless there are well-founded contraindications.

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来源期刊

British journal of anaesthesia 医学-麻醉学

CiteScore

13.50

自引率

7.10%

发文量

488

审稿时长

27 days

期刊介绍： The British Journal of Anaesthesia (BJA) is a prestigious publication that covers a wide range of topics in anaesthesia, critical care medicine, pain medicine, and perioperative medicine. It aims to disseminate high-impact original research, spanning fundamental, translational, and clinical sciences, as well as clinical practice, technology, education, and training. Additionally, the journal features review articles, notable case reports, correspondence, and special articles that appeal to a broader audience. The BJA is proudly associated with The Royal College of Anaesthetists, The College of Anaesthesiologists of Ireland, and The Hong Kong College of Anaesthesiologists. This partnership provides members of these esteemed institutions with access to not only the BJA but also its sister publication, BJA Education. It is essential to note that both journals maintain their editorial independence. Overall, the BJA offers a diverse and comprehensive platform for anaesthetists, critical care physicians, pain specialists, and perioperative medicine practitioners to contribute and stay updated with the latest advancements in their respective fields.