Methionine synthetase A2756G and Cystathionine-β-synthase 844ins68 polymorphisms and coronary artery disease: A meta-analysis.

Objective: Methionine synthetase (MS) A2756G and Cystathionine-β-synthase (CBS) 844ins68 gene polymorphisms were indicated to be associated with increased coronary artery disease (CAD) risk. Nevertheless, because the results of each experiment are different, there is no consensus till now. This meta-analysis aimed to clarify the relationship between MS gene A2756G and CBS gene 844ins68 polymorphisms and CAD.

Methods: 11,555 participants from 24 individual studies, 2162 participants from 6 individual studies were included in the MS gene A2756G and CBS 844ins68 gene polymorphisms meta-analysis respectively. To determine whether MS gene A2756G or CBS gene 844ins68 polymorphism was associated with CAD risk, a random or fixed-effect genetic model was adopted using pooled odds ratios (ORs) and their corresponding 95 % confidence intervals (CIs).

Results: MS gene A2756G polymorphism was significantly associated with CAD under recessive (OR: 1.400, 95 % CI: 1.119-1.751, P = 0.003) and homozygous genetic models (OR: 1.360, 95 % CI: 1.084-1.706, P = 0.008). In the African subgroup, the association was significant under the allelic, recessive, dominant, heterozygous, homozygous and additive (P < 0.05) genetic models. In the Asian subgroup, the association was significant under the allelic, recessive and homozygous genetic models (P < 0.05). No significant association was found between CBS 844ins68 gene polymorphism and CAD under all of the genetic models (P > 0.05).

Conclusions: MS gene A2756G polymorphism was significantly associated with increased CAD risk, especially in the African and Asian population. The G allele carriers of MS gene A2756G polymorphism were more susceptible to be suffered from CAD disease than others.