靶向补体在肾移植中的应用：基于临床前和实验证据的治疗方法

IF 3.6 2区医学 Q2 IMMUNOLOGY

Transplantation Reviews Pub Date : 2024-11-22 DOI:10.1016/j.trre.2024.100887

Daigo Nakazawa

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引用次数: 0

摘要

补体系统涉及肾移植的各个方面，包括缺血再灌注损伤（IRI）、移植物功能延迟、同种异体移植物排斥反应和慢性同种异体移植物损伤。IRI在尸体肾移植中普遍存在，导致急性肾小管坏死，并涉及先天免疫，包括中性粒细胞和补体系统，促进炎症和坏死的循环。实验和临床前证据表明，靶向补体系统可以为肾移植期间IRI提供治疗益处。本文从实验和临床前研究结果出发，探讨了针对补体通路在肾移植中的潜在治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Targeting complement in kidney transplantation: Therapeutic approaches based on preclinical and experimental evidence

The complement system is implicated in various facets of kidney transplantation, including ischemia-reperfusion injury (IRI), delayed graft function, allograft rejection, and chronic allograft injury. IRI, prevalent in cadaveric renal transplantation, leads to acute tubular necrosis and engages innate immunity, including neutrophils and the complement system, fostering a cycle of inflammation and necrosis. Experimental and preclinical evidence suggest that targeting the complement system could offer therapeutic benefits in IRI during kidney transplantation. This article explores potential therapeutic approaches targeting complement pathways in kidney transplantation, drawing from experimental and preclinical research findings.

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来源期刊

Transplantation Reviews IMMUNOLOGY-TRANSPLANTATION

CiteScore

7.50

自引率

2.50%

发文量

审稿时长

29 days

期刊介绍： Transplantation Reviews contains state-of-the-art review articles on both clinical and experimental transplantation. The journal features invited articles by authorities in immunology, transplantation medicine and surgery.