粒细胞集落刺激因子（G-CSF）对急性脊髓损伤患者功能结局的影响：一项单盲随机对照试验

IF 1.5 Q3 ORTHOPEDICS

Journal of orthopaedics Pub Date : 2024-11-26 DOI:10.1016/j.jor.2024.11.025

Prabu Mounissamy , Premraj A.C. , Sushma Chanadrashekar , Naveen Jeyaraman , Swaminathan Ramasubramanian , Madhan Jeyaraman

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引用次数: 0

摘要

脊髓损伤（SCI）是一个重大的公共卫生问题，造成严重的残疾和经济负担。目前的治疗主要集中在减轻继发性损伤，有效的治疗方法有限。本研究探讨了粒细胞集落刺激因子（G-CSF）在改善急性SCI患者功能结局中的作用。材料和方法该单盲随机对照试验在JIPMER骨科进行。急性脊髓损伤（SCI）患者根据特定的纳入和排除标准入组。参与者被分为两组：A组（n = 16）接受G-CSF注射，而B组（n = 18）接受安慰剂（生理盐水）注射。主要评估是基于损伤后1、3和6个月ASIA损伤量表的变化。该研究涉及34名参与者，主要是男性。初步评估显示，两组之间的亚洲得分存在显著差异。与b组相比，A组在治疗后1、3和6个月的神经系统状况有明显改善。两组之间不良事件的频率相当。结论：与安慰剂相比，csf在给药后不同时间点的ASIA评分均有显著改善。这些发现提示G-CSF是一种潜在的治疗急性脊髓损伤的药物。然而，由于样本量较小，需要进一步的研究来证实这些结果。

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Effect of granulocyte colony-stimulating factor (G-CSF) in functional outcome of acute spinal cord injury patients: A single-blinded randomized controlled trial

Background

Spinal Cord Injury (SCI) is a major public health issue causing significant disability and economic burden. Current treatments primarily focus on mitigating secondary injury, with limited effective therapies available. This study explores the efficacy of the Granulocyte Colony-Stimulating Factor (G-CSF) in improving functional outcomes in acute SCI patients.

Materials and methods

This single-blinded randomized control trial was conducted at JIPMER's orthopedic department. Patients with acute spinal cord injury (SCI) were enrolled based on specific inclusion and exclusion criteria. Participants were divided into two groups: Group A (n = 16) received a G-CSF injection whereas Group B (n = 18) received a placebo (normal saline) injection. The primary evaluation was based on the changes in the ASIA impairment scale at 1-, 3-, and 6-months post-injury.

Results

The study involved 34 participants, predominantly male. Initial assessments showed significant differences in ASIA scores between the groups. Group A demonstrated marked improvement in neurological status at 1, 3, and 6 months post-treatment compared to Group B. The frequency of adverse events was comparable between the two groups.

Conclusion

G-CSF showed significant improvement in ASIA scores at various time points post-administration compared to placebo. These findings suggest G-CSF as a potential therapeutic agent in acute SCI treatment. However, due to the small sample size, further research is necessary to confirm these results.

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来源期刊

Journal of orthopaedics ORTHOPEDICS-

CiteScore

3.50

自引率

6.70%

发文量

202

审稿时长

56 days

期刊介绍： Journal of Orthopaedics aims to be a leading journal in orthopaedics and contribute towards the improvement of quality of orthopedic health care. The journal publishes original research work and review articles related to different aspects of orthopaedics including Arthroplasty, Arthroscopy, Sports Medicine, Trauma, Spine and Spinal deformities, Pediatric orthopaedics, limb reconstruction procedures, hand surgery, and orthopaedic oncology. It also publishes articles on continuing education, health-related information, case reports and letters to the editor. It is requested to note that the journal has an international readership and all submissions should be aimed at specifying something about the setting in which the work was conducted. Authors must also provide any specific reasons for the research and also provide an elaborate description of the results.