与 ACE I/D (rs1799752)、ACTN3 (rs1815739)、PPARA (rs4253778) 和 HIF1A (rs11549465) 多态性有关的土耳其冰球运动员运动成绩比较。

IF 1.5 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Canan Sercan Doğan, Orkun Akkoc, Meltem Özağır, Sinan Avci, Selin Biçer Baikoglu, Muhammet İrfan Kurudirek, Korkut Ulucan
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引用次数: 0

摘要

我们的研究旨在检测冰球国家队运动员的 ACE I/D (rs1799752)、ACTN3 (rs1815739)、PPARA (rs4253778) 和 HIF1A (rs11549465) 多态性和体能测试。这项研究有 21 名冰上曲棍球国家队的运动员参加。ACE I/D (rs1799752) 多态性通过传统聚合酶链式反应法(PCR)获得,ACTN3 (rs1815739), PPARA (rs4253778) 和 HIF1A (rs11549465) 多态性通过实时聚合酶链式反应法(qPCR)产生。运动表现分析则基于最大耗氧量(VO2max)、无氧运动表现、柔韧性和力量测试的评估。在我们的队列中,ACE I/D(rs1799752)多态性被确定为基因型 II 的占 24%,基因型 ID 的占 33%,基因型 DD 的占 43%。ACTN3(rs1815739)多态性被确定为24%的基因型为RR,43%的基因型为RX,33%的基因型为XX。PPARA(rs4253778)多态性的基因型为 GG 占 71%,GC 占 14.5%,CC 占 14.5%。HIF1A(rs11549465)多态性的基因型CC占67%,CT占33%。在体能测试方面,对各基因型组间柔韧性测试结果的评估未发现显著差异(P=0.365)。在腿部力量测试结果方面,各基因型组之间没有发现明显差异(P=0.691)。对各基因型组的手握力测试结果进行评估后,未发现明显差异(p=0.679)。在检测最大容氧量测试结果时,各基因型组之间没有发现明显差异(p=0.686)。速度测试与 HIF1A rs11549465 多态性评估有明显关系(p=0.008)。在将速度测试与其他多态性进行比较时,未发现明显结果(p = 0.65)。我们的研究结果支持了之前关注相关基因多态性与冰球运动员运动表现之间潜在关系的研究。然而,为了了解相关基因多态性与冰球运动员运动表现之间的关系,我们建议进行更大规模的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of athletic performance of Turkish ice hockey players with ACE I/D (rs1799752), ACTN3 (rs1815739), PPARA (rs4253778) and HIF1A (rs11549465) polymorphisms.

Our study is aimed at examining the Ice Hockey National Team players with regard to ACE I/D (rs1799752), ACTN3 (rs1815739), PPARA (rs4253778) and HIF1A (rs11549465) polymorphisms and physical tests. This study was participated by 21 players from ice hockey national team. While ACE I/D (rs1799752) polymorphism was obtained using conventional polymerase chain reaction method (PCR), ACTN3 (rs1815739), PPARA (rs4253778) and HIF1A (rs11549465) polymorphisms were produced by real time polymerase chain reaction method (qPCR). Athletic performance analysis, on the other hand, was based on the assessment of maximal oxygen consumption capacity (VO2max), anaerobic performance, flexibility and strength tests. In our cohort, ACE I/D (rs1799752) polymorphism was determined as 24% genotype II, 33% genotype ID, and 43% genotype DD. ACTN3 (rs1815739) polymorphism was determined as 24% genotype RR, 43% genotype RX, and 33% genotype XX. PPARA (rs4253778) polymorphism was observed as 71% genotype GG, 14.5% genotype GC, 14.5% genotype CC. HIF1A (rs11549465) polymorphism was found to be 67% genotype CC, 33% genotype CT. Concerning physical tests, the evaluation of flexibility test results among genotype groups did not yield significant differences (p=0.365). No significant difference was found among genotype groups with respect to leg strength test results (p=0.691). The evaluation of handgrip strength test results among genotype groups did not reveal significant differences (p=0.679). No significant differences were found among genotype groups when VO2 max test results were examined (p=0.686). A significant relationship was found in the speed test and HIF1A rs11549465 polymorphism evaluation (p = 0.008). No significant results were detected when comparing the speed test with other polymorphisms (p = 0.65). The results of our study support the previous studies which had focused on the potential relation between the relevant gene polymorphisms and athletic performance of ice hockey players. However, doing further studies with larger cohorts is recommended in order to understand the relationship between the relevant polymorphisms and athletic performance of ice hockey players.

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来源期刊
Cellular and molecular biology
Cellular and molecular biology 生物-生化与分子生物学
CiteScore
1.60
自引率
12.50%
发文量
331
期刊介绍: Cellular and Molecular Biology publishes original articles, reviews, short communications, methods, meta-analysis notes, letters to editor and comments in the interdisciplinary science of Cellular and Molecular Biology linking and integrating molecular biology, biophysics, biochemistry, enzymology, physiology and biotechnology in a dynamic cell and tissue biology environment, applied to human, animals, plants tissues as well to microbial and viral cells. The journal Cellular and Molecular Biology is therefore open to intense interdisciplinary exchanges in medical, dental, veterinary, pharmacological, botanical and biological researches for the demonstration of these multiple links.
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