早发转移性结直肠癌患者是一种独特的临床和分子现象。

IF 6.4 1区 医学 Q1 ONCOLOGY
Andrea Pretta, Pina Ziranu, Eleonora Perissinotto, Filippo Ghelardi, Federica Marmorino, Riccardo Giampieri, Mariangela Puci, Maria Caterina De Grandis, Eleonora Lai, Vincenzo Nasca, Paolo Ciraci, Marco Puzzoni, Krisida Cerma, Carolina Sciortino, Ada Taravella, Gianluca Pretta, Lorenzo Giuliani, Camilla Damonte, Valeria Pusceddu, Giovanni Sotgiu, Rossana Berardi, Sara Lonardi, Francesca Bergamo, Filippo Pietrantonio, Chiara Cremolini, Mario Scartozzi
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引用次数: 0

摘要

背景:尽管儿童癌症的发病率和死亡率都有所下降,但最近的研究表明,早发儿童癌症(EO-CRC)的发病率有所上升。关于这种情况的数据很有限。我们的研究旨在评估转移性 EO-CRC 患者的临床和分子特征,以确定与晚发性 CRC(LO-CRC)对照组相比的差异:我们回顾性地收集了来自意大利 5 家不同机构的 1272 例转移性结直肠癌患者的数据。主要目的是评估 EO-CRC 患者与对照组患者的临床结果:结果:在总体人群中,EO-CRC 患者的生存期为 34.7 个月,对照组为 43.0 个月:研究结果表明,与晚期患者相比,早期结直肠癌患者的预后普遍较差。有趣的是,这种情况似乎与分子状态无关。这些观察结果可能会对临床实践和研究产生重大影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Early onset metastatic colorectal cancer patients as a distinctive clinical and molecular phenomenon.

Background: Despite a reduction of both incidence and mortality from CRC, recent studies have shown an increase in the incidence of early-onset CRC (EO-CRC). Data on this setting are limited. The aim of our study was to evaluate the clinical and molecular profiles of metastatic EO-CRC patients in order to identify differences compared to a late-onset CRC (LO-CRC) control group.

Methods: We retrospectively collected data from 1272 metastatic colorectal cancers from 5 different Italian Institutions. The main objective was to the evaluate clinical outcome for EO-CRC patients in comparison to patients included in the control group.

Results: In the overall population, mOS was 34,7 in EO-CRC pts vs 43,0 months (mo) (p < 0,0001). In the RAS/BRAF mutated subgroup mOS in EO-CRC pts was 30,3 vs 34,0 mo (p = 0,0156). In RAS/BRAF wild-type EO-CRC mOS was 43,0 vs 50,0 mo (p = 0,0290). mPFS was 11,0 in EO-CRC pts vs 14,0 mo (p < 0,0001).

Conclusion: Findings indicate a general worse prognosis for patients with early-onset colorectal cancer compared to late-onset patients. Interestingly this seems to occur regardless of the molecular status. These observations might have a considerable impact on clinical practice and research.

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来源期刊
British Journal of Cancer
British Journal of Cancer 医学-肿瘤学
CiteScore
15.10
自引率
1.10%
发文量
383
审稿时长
6 months
期刊介绍: The British Journal of Cancer is one of the most-cited general cancer journals, publishing significant advances in translational and clinical cancer research.It also publishes high-quality reviews and thought-provoking comment on all aspects of cancer prevention,diagnosis and treatment.
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