德累斯顿方案与加速法在儿童患者中的角膜交联--一项回顾性比较研究。

IF 1.1 4区 医学 Q3 OPHTHALMOLOGY
Arquivos brasileiros de oftalmologia Pub Date : 2024-11-22 eCollection Date: 2024-01-01 DOI:10.5935/0004-2749.2023-0309
Júlia Maggi Vieira, Isadora Brito Coelho, Fellype Borges de Oliveira, Heloisa Nascimento, Fábio Nishimura Kanadani, Evandro Ribeiro Diniz
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引用次数: 0

摘要

目的:与成人相比,小儿角膜病具有某些特殊性。儿童患者面临的最大挑战是病情更严重、进展更快。在这项回顾性研究中,我们对加速角膜交联法和德累斯顿角膜交联法进行了比较:两种方案都能有效阻止角膜病的发展。在 12 个月的随访中,没有患者病情恶化。只有在德累斯顿方案组中观察到 Kmax 明显降低,矫正距离视力明显提高。虽然德累斯顿方案在降低Kmax方面优于加速方案(P=0.002),但两组患者的矫正远视力没有明显差异:结论:在稳定角膜病进展方面,加速方案与德累斯顿方案同样有效。虽然德累斯顿方案在降低 Kmax 方面优于加速方案,但并没有产生更好的临床效果。因此,加速方案是一种有效的选择。此外,考虑到缩短手术时间的优势,加速方案能有效阻止儿童角膜病的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Corneal crosslinking via the Dresden protocol versus the accelerated approach in pediatric patients - a retrospective comparative study.

Purpose: Keratoconus presents certain peculiarities in pediatric patients when compared with adults. The greatest challenge in children is that the disease is more severe and faster in progression. In this retrospective study, we aimed to compare the accelerated and Dresden protocols for corneal crosslinking in patients aged <18 years who were followed-up for at least 12 months. Methods: A total of 36 eyes from 27 patients were included in the study. The best corrected and uncorrected visual acuity, maximal keratometry, corneal thickness, foveal thickness, and endothelial microscopy findings were evaluated at baseline and during the postoperative period at one, three, and six months. Thereafter, the patients were evaluated at one, three, six and twelve months postoperative. Corneal crosslinking was performed in all patients via the Dresden protocol (n=21 eyes) or the accelerated protocol (n=15 eyes). Data between the two groups were compared and XY statistical analysis was used.

Results: Both protocols were effective in halting keratoconus progression. No patient had progression at the 12-month follow-up. A significant reduction in Kmax and improvement in the corrected distance visual acuity were observed only in the Dresden protocol group. Although the Dresden protocol was superior to the accelerated protocol in reducing Kmax (p=0.002), there was no significant difference in corrected distance visual acuity between the two groups.

Conclusion: The accelerated protocol is as efficient as the Dresden protocol in stabilizing keratoconus progression. Although the Dresden protocol was superior to the accelerated protocol in reducing the Kmax, it did not produce better clinical results. Thus, the accelerated protocol is an efficient option. Furthermore, considering the advantages of reduced surgical time, the accelerated protocol is effective in halting keratoconus progression in the pediatric age group.

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来源期刊
CiteScore
1.60
自引率
0.00%
发文量
200
审稿时长
6-12 weeks
期刊介绍: The ABO-ARQUIVOS BRASILEIROS DE OFTALMOLOGIA (ABO, ISSN 0004-2749 - print and ISSN 1678-2925 - (ABO, ISSN 0004-2749 - print and ISSN 1678-2925 - electronic version), the official bimonthly publication of the Brazilian Council of Ophthalmology (CBO), aims to disseminate scientific studies in Ophthalmology, Visual Science and Health public, by promoting research, improvement and updating of professionals related to the field.
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