4-Iodotoluene 催化 1,n-炔的电化学二氯环化反应。

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-12-13 Epub Date: 2024-11-28 DOI:10.1021/acs.orglett.4c04041

Xu Wang, Longji Li, Zhongjian Du, Xingmin Han, Yang'en You

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引用次数: 0

摘要

据报道，有一种电化学方法可间接氧化生成作为反应催化剂的高价碘代烯烃。该反应首先通过电氧化生成活性 Cl 物种，然后通过氧化转移生成 ArICl2，ArICl2 随后与烯炔反应实现环化。该方案提供了一种简单、绿色的方法，可以高产率、高选择性地获得二氯化环化产物。

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Electrochemical Dichlorinative Cyclization of 1,n-Enynes by 4-Iodotoluene Catalysis.

An electrochemical approach for the indirect oxidative generation of hypervalent iodoarene as a reaction catalyst has been reported. The reaction proceeds first from the generation of active Cl species by electro-oxidation, followed by oxidative transfer to generate ArICl₂, which subsequently reacts with enynes to achieve cyclization. This protocol provides a simple and green method for accessing dichlorinative cyclization products in high yields with good selectivity.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.