钯/降冰片烯介导的级联环化对中等尺寸多环亚甲基亚磺酰亚胺的双惰性 C-H 键位点选择性活化。

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-11-28 DOI:10.1021/acs.orglett.4c03935

Li Wei, Fang Xun, Xiaojuan Chen, Ting Chen, Zhiyuan Chen

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引用次数: 0

摘要

报告了一种由钯/降冰片烯介导的三组分模块化一步反应，该反应通过双重 C-H 键活化和级联环化得以实现。该反应使用降冰片烯作为卡泰拉尼型反应的催化剂和烷基化结构单元来完成双重未活化 C-H 键官能化协议，从而生产出具有茚融合分子的多杂环八元亚磺酰亚胺。这种温和、可扩展的方案具有广泛的底物范围，是在高化学选择性芳基位点进行位点选择性双 C-H 功能化的理想选择。

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Dual Inert C-H Bond Site-Selective Activations Enabled by Pd/Norbornene-Mediated Cascade Cyclization toward Medium-Sized Polyheterocyclic Methylene Sulfoximines.

A Pd/norbornene-mediated three-component modular one-step reaction facilitated by dual C-H bond activation and cascade cyclization is reported. This procedure uses norbornene as a catalyst in the Catellani-type reaction and as an alkylating building block to accomplish the dual unactivated C-H bond functionalization protocol, which results in the production of polyheterocyclic eight-membered sulfoximines with an indene-fused moiety. This mild, scalable protocol's wide substrate range makes it ideal for site-selective dual C-H functionalization at the highly chemoselective aryl sites.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.