Reshma Raju, Luke O'Neil, Charlotte Kerr, Burhan Lehri, Sudipta Sarkar, Twinkle Soni, Patrick Nguipdop-Djomo, Anne Conan, Nguyen Dong Tu, Tran Thi Mai Hung, Melanie Hay, Jane Falconer, Fiona Tomley, Damer Blake, Guillaume Fournié, Sitara Swarna Rao Ajjampur, Punam Mangtani, Richard Stabler
{"title":"印度、越南、孟加拉国和斯里兰卡人体内的非伤寒沙门氏菌：系统综述。","authors":"Reshma Raju, Luke O'Neil, Charlotte Kerr, Burhan Lehri, Sudipta Sarkar, Twinkle Soni, Patrick Nguipdop-Djomo, Anne Conan, Nguyen Dong Tu, Tran Thi Mai Hung, Melanie Hay, Jane Falconer, Fiona Tomley, Damer Blake, Guillaume Fournié, Sitara Swarna Rao Ajjampur, Punam Mangtani, Richard Stabler","doi":"10.1093/jacamr/dlae190","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Non-typhoidal <i>Salmonella</i> (NTS) commonly causes a self-limiting illness but invasive disease (iNTS) can be life-threatening. Antimicrobial resistance (AMR) increases the risk of mortality. This systematic review aimed to estimate the proportion of NTS isolated in those attending healthcare services, serovar burden, AMR, serovar-specific AMR, and case fatality rate (CFR) in India, Bangladesh, Sri Lanka and Vietnam.</p><p><strong>Methods: </strong>The review included quantitative studies on NTS and AMR from 1980 to 2020 but excluded studies unrelated to humans or selected countries. Data were extracted from articles identified from Ovid SP, Web of Science, Wiley Cochrane Library, Elsevier Scopus and WHO Global Index Medicus. The Joanna Briggs Institute Critical Appraisal Tools Checklist for Prevalence Studies was used for risk-of-bias assessment. Meta-analyses were performed for the proportion of NTS isolated, the proportion of specific serovars isolated, percentage of AMR and CFR.</p><p><strong>Results: </strong>Six thousand and twenty-six isolates (79 serovars) were identified from 73 studies, with <i>Salmonella enterica</i> serovar Typhimurium being the most common. Of the 73 selected studies, 46% were hospital/laboratory surveillance studies, examining the aetiology of invasive or non-invasive infections. The pooled proportion estimate for non-iNTS was 2.1% (95% CI: 1.2%-3.2%) and for iNTS was 0.3% (95% CI: 0.1%-0.5%). The pooled CFR was 14.9% (95% CI: 4.0%-29.6%). Pooled resistance estimates for ampicillin, ceftriaxone, chloramphenicol, ciprofloxacin, co-trimoxazole, nalidixic acid and azithromycin were calculated. MDR iNTS was less prevalent in India [22.3% (95% CI: 0.0%-66.8%)] than in Vietnam [41.2% (95% CI: 33.6%-49.3%)]. Heterogeneity of studies was high as the majority were observational surveillance studies.</p><p><strong>Conclusions: </strong>Despite data scarcity in some countries, this review highlights the continued contribution of NTS infection to disease burden, compounded by high AMR rates.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":"6 6","pages":"dlae190"},"PeriodicalIF":3.7000,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589464/pdf/","citationCount":"0","resultStr":"{\"title\":\"Non-typhoidal <i>Salmonella</i> in humans in India, Vietnam, Bangladesh and Sri Lanka: a systematic review.\",\"authors\":\"Reshma Raju, Luke O'Neil, Charlotte Kerr, Burhan Lehri, Sudipta Sarkar, Twinkle Soni, Patrick Nguipdop-Djomo, Anne Conan, Nguyen Dong Tu, Tran Thi Mai Hung, Melanie Hay, Jane Falconer, Fiona Tomley, Damer Blake, Guillaume Fournié, Sitara Swarna Rao Ajjampur, Punam Mangtani, Richard Stabler\",\"doi\":\"10.1093/jacamr/dlae190\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Non-typhoidal <i>Salmonella</i> (NTS) commonly causes a self-limiting illness but invasive disease (iNTS) can be life-threatening. Antimicrobial resistance (AMR) increases the risk of mortality. This systematic review aimed to estimate the proportion of NTS isolated in those attending healthcare services, serovar burden, AMR, serovar-specific AMR, and case fatality rate (CFR) in India, Bangladesh, Sri Lanka and Vietnam.</p><p><strong>Methods: </strong>The review included quantitative studies on NTS and AMR from 1980 to 2020 but excluded studies unrelated to humans or selected countries. Data were extracted from articles identified from Ovid SP, Web of Science, Wiley Cochrane Library, Elsevier Scopus and WHO Global Index Medicus. The Joanna Briggs Institute Critical Appraisal Tools Checklist for Prevalence Studies was used for risk-of-bias assessment. Meta-analyses were performed for the proportion of NTS isolated, the proportion of specific serovars isolated, percentage of AMR and CFR.</p><p><strong>Results: </strong>Six thousand and twenty-six isolates (79 serovars) were identified from 73 studies, with <i>Salmonella enterica</i> serovar Typhimurium being the most common. Of the 73 selected studies, 46% were hospital/laboratory surveillance studies, examining the aetiology of invasive or non-invasive infections. The pooled proportion estimate for non-iNTS was 2.1% (95% CI: 1.2%-3.2%) and for iNTS was 0.3% (95% CI: 0.1%-0.5%). The pooled CFR was 14.9% (95% CI: 4.0%-29.6%). Pooled resistance estimates for ampicillin, ceftriaxone, chloramphenicol, ciprofloxacin, co-trimoxazole, nalidixic acid and azithromycin were calculated. MDR iNTS was less prevalent in India [22.3% (95% CI: 0.0%-66.8%)] than in Vietnam [41.2% (95% CI: 33.6%-49.3%)]. Heterogeneity of studies was high as the majority were observational surveillance studies.</p><p><strong>Conclusions: </strong>Despite data scarcity in some countries, this review highlights the continued contribution of NTS infection to disease burden, compounded by high AMR rates.</p>\",\"PeriodicalId\":14594,\"journal\":{\"name\":\"JAC-Antimicrobial Resistance\",\"volume\":\"6 6\",\"pages\":\"dlae190\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-11-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589464/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JAC-Antimicrobial Resistance\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/jacamr/dlae190\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JAC-Antimicrobial Resistance","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/jacamr/dlae190","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
摘要
目的：非伤寒沙门氏菌（NTS）通常会引起自限性疾病，但侵袭性疾病（iNTS）可能会危及生命。抗菌药耐药性（AMR）会增加死亡风险。本系统综述旨在估算印度、孟加拉国、斯里兰卡和越南在就诊者中分离出的 NTS 比例、血清型负担、AMR、血清型特异性 AMR 和病死率 (CFR)：综述包括 1980 年至 2020 年有关 NTS 和 AMR 的定量研究，但排除了与人类或选定国家无关的研究。数据提取自 Ovid SP、Web of Science、Wiley Cochrane Library、Elsevier Scopus 和 WHO Global Index Medicus 中的文章。评估偏倚风险时使用了乔安娜-布里格斯研究所（Joanna Briggs Institute）的流行病学研究批判性评估工具核对表。对NTS分离比例、特定血清分离比例、AMR比例和CFR进行了元分析：结果：从 73 项研究中发现了 626 个分离菌株（79 个血清型），其中最常见的是鼠伤寒沙门氏菌。在所选的 73 项研究中，46% 为医院/实验室监测研究，考察的是侵袭性或非侵袭性感染的病原学。非侵入性感染的汇总比例估计值为 2.1%（95% CI：1.2%-3.2%），侵入性感染的汇总比例估计值为 0.3%（95% CI：0.1%-0.5%）。综合耐药率为 14.9%（95% CI：4.0%-29.6%）。计算了氨苄西林、头孢曲松、氯霉素、环丙沙星、联合曲唑、萘啶酸和阿奇霉素的集合耐药性估计值。印度的 MDR iNTS 患病率[22.3%（95% CI：0.0%-66.8%）]低于越南[41.2%（95% CI：33.6%-49.3%）]。由于大多数研究都是观察性监测研究，因此研究的异质性很高：尽管一些国家的数据稀缺，但本综述强调了 NTS 感染对疾病负担的持续影响，而高 AMR 率又加剧了这种影响。
Non-typhoidal Salmonella in humans in India, Vietnam, Bangladesh and Sri Lanka: a systematic review.
Objectives: Non-typhoidal Salmonella (NTS) commonly causes a self-limiting illness but invasive disease (iNTS) can be life-threatening. Antimicrobial resistance (AMR) increases the risk of mortality. This systematic review aimed to estimate the proportion of NTS isolated in those attending healthcare services, serovar burden, AMR, serovar-specific AMR, and case fatality rate (CFR) in India, Bangladesh, Sri Lanka and Vietnam.
Methods: The review included quantitative studies on NTS and AMR from 1980 to 2020 but excluded studies unrelated to humans or selected countries. Data were extracted from articles identified from Ovid SP, Web of Science, Wiley Cochrane Library, Elsevier Scopus and WHO Global Index Medicus. The Joanna Briggs Institute Critical Appraisal Tools Checklist for Prevalence Studies was used for risk-of-bias assessment. Meta-analyses were performed for the proportion of NTS isolated, the proportion of specific serovars isolated, percentage of AMR and CFR.
Results: Six thousand and twenty-six isolates (79 serovars) were identified from 73 studies, with Salmonella enterica serovar Typhimurium being the most common. Of the 73 selected studies, 46% were hospital/laboratory surveillance studies, examining the aetiology of invasive or non-invasive infections. The pooled proportion estimate for non-iNTS was 2.1% (95% CI: 1.2%-3.2%) and for iNTS was 0.3% (95% CI: 0.1%-0.5%). The pooled CFR was 14.9% (95% CI: 4.0%-29.6%). Pooled resistance estimates for ampicillin, ceftriaxone, chloramphenicol, ciprofloxacin, co-trimoxazole, nalidixic acid and azithromycin were calculated. MDR iNTS was less prevalent in India [22.3% (95% CI: 0.0%-66.8%)] than in Vietnam [41.2% (95% CI: 33.6%-49.3%)]. Heterogeneity of studies was high as the majority were observational surveillance studies.
Conclusions: Despite data scarcity in some countries, this review highlights the continued contribution of NTS infection to disease burden, compounded by high AMR rates.
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