壳聚糖-金属杂化物支架作为抗菌伤口敷料

IF 5.3 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Liquids Pub Date : 2024-11-23 DOI:10.1016/j.molliq.2024.126541

Shengyu Zhang , Muhammad Ali , Farooq Nawaz , Nisar Ali , Adnan Khan , Farman Ali , Muhammad Hamid Khan , Sidra , Shakeel Ahmad , Suhaib Rahman , Arif Nawaz , Rayya Ahmed Al Balushi , Mohammad M. Al-Hinaai , Thuraya Al-Harthy

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引用次数: 0

摘要

甲壳素提取自甲壳素，甲壳素是一种天然多糖，存在于虾、蟹和龙虾等甲壳类动物的外骨骼中。甲壳素经过脱乙酰化后成为壳聚糖，壳聚糖有多种用途，如制药、食品加工和化妆品。由于甲壳素具有加速伤口愈合的潜力，它已被广泛研究用于伤口敷料。本研究的目的是利用壳聚糖和金属纳米复合材料的协同效应来提高抗菌效果并促进伤口的最佳愈合，从而解决传统伤口敷料的局限性。壳聚糖基纳米复合材料支架在医学领域的应用日益广泛，尤其是在药物输送、组织工程和伤口愈合方面。支架在伤口愈合中起着至关重要的作用，它提供了支持组织再生的物理结构，并提供了结构支持、生物相容性和抗菌活性的独特组合。壳聚糖的生物相容性可确保将对组织的刺激降至最低，使其成为伤口敷料的理想选择。在壳聚糖基质中加入纳米金属成分具有重要的伤口敷料潜力。这篇综述介绍了壳聚糖-金属纳米复合材料的各种组合，如壳聚糖/nAg、壳聚糖/nAu、壳聚糖/nCu、壳聚糖/nZnO 和壳聚糖/nTiO2，重点介绍了它们在改善伤口愈合和感染方面的贡献，特别着重解释了其毒性和抗菌作用机制。

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Scaffolds of Chitosan-metallic hybrids as antimicrobial wound dressing

Chitosan is derived from chitin, which is a naturally occurring polysaccharide found in the exoskeletons of crustaceans like shrimp, crab, and lobster. Chitin undergoes deacetylation, to chitosan, which has various applications such as pharmaceuticals, food processing, and cosmetics. It has been widely investigated for wound dressings due to its potential to accelerate wound healing. The aim of this research addresses the limitations of traditional wound dressings by harnessing the synergistic effects of Chitosan and metallic nanocomposites to enhance antimicrobial efficacy and promote optimal wound healing. Chitosan-based nanocomposite scaffolds have gained expanded applications in the medical field, particularly in drug delivery, tissue engineering, and wound healing. Scaffolds play a crucial role in wound healing, providing a physical structure to support tissue regeneration and offer a unique combination of structural support, biocompatibility, and antimicrobial activity. Chitosan’s biocompatibility ensures minimal tissue irritation, making it an ideal candidate for wound dressings. The incorporation of nanometallic components into the chitosan matrix holds important potential for wound dressings. This review explains various combinations of chitosan-metal nanocomposites, such as Chitosan/nAg, Chitosan/nAu, Chitosan/nCu, Chitosan/nZnO, and Chitosan/nTiO₂, focusing on their contributions for the improvement of healing and infections, specifically focusing on explaining the toxicity and antimicrobial mechanisms of action.

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来源期刊

Journal of Molecular Liquids 化学-物理：原子、分子和化学物理

CiteScore

10.30

自引率

16.70%

发文量

2597

审稿时长

78 days

期刊介绍： The journal includes papers in the following areas: – Simple organic liquids and mixtures – Ionic liquids – Surfactant solutions (including micelles and vesicles) and liquid interfaces – Colloidal solutions and nanoparticles – Thermotropic and lyotropic liquid crystals – Ferrofluids – Water, aqueous solutions and other hydrogen-bonded liquids – Lubricants, polymer solutions and melts – Molten metals and salts – Phase transitions and critical phenomena in liquids and confined fluids – Self assembly in complex liquids.– Biomolecules in solution The emphasis is on the molecular (or microscopic) understanding of particular liquids or liquid systems, especially concerning structure, dynamics and intermolecular forces. The experimental techniques used may include: – Conventional spectroscopy (mid-IR and far-IR, Raman, NMR, etc.) – Non-linear optics and time resolved spectroscopy (psec, fsec, asec, ISRS, etc.) – Light scattering (Rayleigh, Brillouin, PCS, etc.) – Dielectric relaxation – X-ray and neutron scattering and diffraction. Experimental studies, computer simulations (MD or MC) and analytical theory will be considered for publication; papers just reporting experimental results that do not contribute to the understanding of the fundamentals of molecular and ionic liquids will not be accepted. Only papers of a non-routine nature and advancing the field will be considered for publication.