硒吩并[2,3-c/3,2-c] 吡唑杂环的合成、反应性和生物活性研究的最新进展

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry Pub Date : 2024-11-24 DOI:10.1016/j.jorganchem.2024.123447

Moustafa A. Gouda , Osama Alharbi , Nahlah A. Al-Hadhrami , Reem A.K. Alharbi , Rasha Jame

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引用次数: 0

摘要

吡唑和硒吩是有价值的杂环化合物，在新药物分子的开发中起着至关重要的作用。将硒吩和吡唑分子结合成杂交结构，为各种药理活性提供了令人兴奋的可能性，从而发现了硒吩并吡唑，包括硒吩并[2,3-c]吡唑和硒吩并[3,2-c]吡唑。所有这些都表现出令人感兴趣的特性。硒吩并吡唑可通过几种化学反应合成：Vilsmeier-Haack 反应、Thorpe-Ziegler 环化反应和铃木交叉偶联反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Recent progress in synthesis, reactivity, and biological activities of selenopheno[2,3-c/3,2-c] pyrazole heterocycles

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Recent progress in synthesis, reactivity, and biological activities of selenopheno[2,3-c/3,2-c] pyrazole heterocycles

Pyrazole and selenophene are valuable heterocyclic compounds that play a crucial role in the development of new drug molecules. Combining the selenophene and pyrazole moieties to hybrid structures has opened exciting possibilities for various pharmacological activities, leading to the discovery of selenophenopyrazoles, including selenopheno[2,3-c]pyrazole and selenopheno[3,2-c]pyrazole. All of which exhibit intriguing properties. The synthesis of selenophenopyrazoles can be accomplished through several chemical reactions: Vilsmeier–Haack reaction, Thorpe–Ziegler cyclization, and Suzuki cross-coupling.

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来源期刊

Journal of Organometallic Chemistry 化学-无机化学与核化学

CiteScore

4.40

自引率

8.70%

发文量

221

审稿时长

36 days

期刊介绍： The Journal of Organometallic Chemistry targets original papers dealing with theoretical aspects, structural chemistry, synthesis, physical and chemical properties (including reaction mechanisms), and practical applications of organometallic compounds. Organometallic compounds are defined as compounds that contain metal - carbon bonds. The term metal includes all alkali and alkaline earth metals, all transition metals and the lanthanides and actinides in the Periodic Table. Metalloids including the elements in Group 13 and the heavier members of the Groups 14 - 16 are also included. The term chemistry includes syntheses, characterizations and reaction chemistry of all such compounds. Research reports based on use of organometallic complexes in bioorganometallic chemistry, medicine, material sciences, homogeneous catalysis and energy conversion are also welcome. The scope of the journal has been enlarged to encompass important research on organometallic complexes in bioorganometallic chemistry and material sciences, and of heavier main group elements in organometallic chemistry. The journal also publishes review articles, short communications and notes.