The relationship between systemic inflammation response index and clinical and histopathological features in gastric cancer.

Objective: The systemic inflammation response index (SIRI) is a marker used to predict survival. The aim of this study is to examine the relationship between SIRI and clinicopathological features and survival.

Method: The relationship between clinicopathological characteristics and survey and SIRI was retrospectively investigated.

Results: A total of 178 patients were included in the study. Poor prognostic factors such as tumor size, t, T-stage, tumor-node-metastasis (TNM) stage, and CA19-9 level were found to have a statistically significant relationship with patients with high SIRI (p = 0.039, p = 0.001, p = 0.001 and p = 0.013, respectively). A high SIRI was found to be an independent and poor prognostic factor for 3-year and 5-year survival (p = 0.014 and p = 0.027, respectively).

Conclusions: High SIRI was associated with a poor survival rate, as were advanced TNM stage, advanced T stage, larger tumor size, and elevated CA19-9 level; all these are poor prognostic markers for gastric cancer.