{"title":"胎膜早破后宫颈环扎术的管理:主张去除宫颈环扎:早产胎膜早破后立即去除宫颈环扎。","authors":"Fabrizio Zullo, Daniele DI Mascio","doi":"10.1016/j.ajogmf.2024.101570","DOIUrl":null,"url":null,"abstract":"<p><p>Cervical cerclage is a widely used intervention to prevent PTB in high-risk pregnancies. However, cerclage carries risks, including preterm prelabor rupture of membranes (PPROM) and subsequent complications such as chorioamnionitis. Our review evaluates the evidence for immediate removal (i.e. removal at time of diagnosis) versus retention of cervical cerclage (i.e. removal when clinically indicated) following PPROM, focusing on optimizing neonatal outcomes and minimizing maternal and fetal complications. A meta-analysis on the topic that included 169 patients in the \"removal\" group and 208 in the \"retention\" group showed that the rate of pregnancy prolongation > 48 hours was significantly lower in the group undergoing immediate removal of cerclage (47% vs 85%; OR 0.15), as well as the rate of pregnancy prolongation > 7 days (33% vs 57%; OR 0.30). Pregnancy latency was also significantly lower despite the absolute mean difference was only 2.84 days. However, the rate of chorioamnionitis was significantly lower in the immediate removal compared to the retention group (29% vs 41%; OR 0.57), as well as the rate of Apgar score < 7 at 5 minutes (16% vs 43%; OR 0.22). A proposed balanced approach involves retaining the cerclage for approximately 24 hours post-PROM to permit steroid administration (initial dose followed by a second dose after 24 hours) before removal. This strategy aims to maximize steroid benefits while minimizing the risks of prolonged cerclage retention, potentially achieving a correct timing that optimizes neonatal outcomes without significantly increasing complications This management approach could be beneficial in situations where immediate removal may preclude full steroid benefits. Our recommendations support a protocol balancing appropriate timing for steroid administration with the risks of extended cerclage retention, namely chorioamnionitis, unless further randomized controlled trials will show the proper evidence based management in this clinical scenario.</p>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":" ","pages":"101570"},"PeriodicalIF":3.8000,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Management of Cervical Cerclage after Premature Preterm Rupture of Membranes: An argument for removal: Immediate removal of cerclage after PPROM.\",\"authors\":\"Fabrizio Zullo, Daniele DI Mascio\",\"doi\":\"10.1016/j.ajogmf.2024.101570\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cervical cerclage is a widely used intervention to prevent PTB in high-risk pregnancies. However, cerclage carries risks, including preterm prelabor rupture of membranes (PPROM) and subsequent complications such as chorioamnionitis. Our review evaluates the evidence for immediate removal (i.e. removal at time of diagnosis) versus retention of cervical cerclage (i.e. removal when clinically indicated) following PPROM, focusing on optimizing neonatal outcomes and minimizing maternal and fetal complications. A meta-analysis on the topic that included 169 patients in the \\\"removal\\\" group and 208 in the \\\"retention\\\" group showed that the rate of pregnancy prolongation > 48 hours was significantly lower in the group undergoing immediate removal of cerclage (47% vs 85%; OR 0.15), as well as the rate of pregnancy prolongation > 7 days (33% vs 57%; OR 0.30). Pregnancy latency was also significantly lower despite the absolute mean difference was only 2.84 days. However, the rate of chorioamnionitis was significantly lower in the immediate removal compared to the retention group (29% vs 41%; OR 0.57), as well as the rate of Apgar score < 7 at 5 minutes (16% vs 43%; OR 0.22). A proposed balanced approach involves retaining the cerclage for approximately 24 hours post-PROM to permit steroid administration (initial dose followed by a second dose after 24 hours) before removal. This strategy aims to maximize steroid benefits while minimizing the risks of prolonged cerclage retention, potentially achieving a correct timing that optimizes neonatal outcomes without significantly increasing complications This management approach could be beneficial in situations where immediate removal may preclude full steroid benefits. 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引用次数: 0
摘要
宫颈环扎术是预防高危妊娠先兆流产的一种广泛应用的干预措施。然而,宫颈环扎术也存在风险,包括产前胎膜早破(PPROM)和随后的并发症,如绒毛膜羊膜炎。我们的综述评估了在产前胎膜早破(PPROM)后立即取出宫颈环扎(即在诊断时取出)与保留宫颈环扎(即在有临床指征时取出)的证据,重点是优化新生儿预后和减少母体及胎儿并发症。一项纳入了 169 名 "去除 "组和 208 名 "保留 "组患者的荟萃分析显示,立即去除宫颈环扎组的妊娠时间延长超过 48 小时的比率显著降低(47% 对 85%;OR 0.15),妊娠时间延长超过 7 天的比率也显著降低(33% 对 57%;OR 0.30)。尽管绝对平均差异仅为 2.84 天,但妊娠潜伏期也明显缩短。然而,与保留宫颈组相比,立即取出宫颈组的绒毛膜羊膜炎发生率明显降低(29% vs 41%; OR 0.57),5 分钟时阿普加评分小于 7 分的发生率也明显降低(16% vs 43%; OR 0.22)。一种建议的平衡方法是在宫颈环扎术后保留宫颈环扎约 24 小时,以便在移除前给予类固醇(首次剂量,24 小时后再给第二次剂量)。这种策略旨在最大限度地发挥类固醇的作用,同时最大限度地降低长时间保留环扎带来的风险,从而在不显著增加并发症的情况下实现最佳的新生儿预后。除非进一步的随机对照试验能证明在这种临床情况下有适当的循证管理方法,否则我们的建议支持在适当的类固醇给药时机与环扎滞留时间过长的风险(即绒毛膜羊膜炎)之间取得平衡的方案。
Management of Cervical Cerclage after Premature Preterm Rupture of Membranes: An argument for removal: Immediate removal of cerclage after PPROM.
Cervical cerclage is a widely used intervention to prevent PTB in high-risk pregnancies. However, cerclage carries risks, including preterm prelabor rupture of membranes (PPROM) and subsequent complications such as chorioamnionitis. Our review evaluates the evidence for immediate removal (i.e. removal at time of diagnosis) versus retention of cervical cerclage (i.e. removal when clinically indicated) following PPROM, focusing on optimizing neonatal outcomes and minimizing maternal and fetal complications. A meta-analysis on the topic that included 169 patients in the "removal" group and 208 in the "retention" group showed that the rate of pregnancy prolongation > 48 hours was significantly lower in the group undergoing immediate removal of cerclage (47% vs 85%; OR 0.15), as well as the rate of pregnancy prolongation > 7 days (33% vs 57%; OR 0.30). Pregnancy latency was also significantly lower despite the absolute mean difference was only 2.84 days. However, the rate of chorioamnionitis was significantly lower in the immediate removal compared to the retention group (29% vs 41%; OR 0.57), as well as the rate of Apgar score < 7 at 5 minutes (16% vs 43%; OR 0.22). A proposed balanced approach involves retaining the cerclage for approximately 24 hours post-PROM to permit steroid administration (initial dose followed by a second dose after 24 hours) before removal. This strategy aims to maximize steroid benefits while minimizing the risks of prolonged cerclage retention, potentially achieving a correct timing that optimizes neonatal outcomes without significantly increasing complications This management approach could be beneficial in situations where immediate removal may preclude full steroid benefits. Our recommendations support a protocol balancing appropriate timing for steroid administration with the risks of extended cerclage retention, namely chorioamnionitis, unless further randomized controlled trials will show the proper evidence based management in this clinical scenario.
期刊介绍:
The American Journal of Obstetrics and Gynecology (AJOG) is a highly esteemed publication with two companion titles. One of these is the American Journal of Obstetrics and Gynecology Maternal-Fetal Medicine (AJOG MFM), which is dedicated to the latest research in the field of maternal-fetal medicine, specifically concerning high-risk pregnancies. The journal encompasses a wide range of topics, including:
Maternal Complications: It addresses significant studies that have the potential to change clinical practice regarding complications faced by pregnant women.
Fetal Complications: The journal covers prenatal diagnosis, ultrasound, and genetic issues related to the fetus, providing insights into the management and care of fetal health.
Prenatal Care: It discusses the best practices in prenatal care to ensure the health and well-being of both the mother and the unborn child.
Intrapartum Care: It provides guidance on the care provided during the childbirth process, which is critical for the safety of both mother and baby.
Postpartum Issues: The journal also tackles issues that arise after childbirth, focusing on the postpartum period and its implications for maternal health. AJOG MFM serves as a reliable forum for peer-reviewed research, with a preference for randomized trials and meta-analyses. The goal is to equip researchers and clinicians with the most current information and evidence-based strategies to effectively manage high-risk pregnancies and to provide the best possible care for mothers and their unborn children.