药理抑制 SRF 活性的新见解：关键抑制靶点和机制

IF 3.5 3区医学 Q2 PHARMACOLOGY & PHARMACY

Vascular pharmacology Pub Date : 2024-12-01 DOI:10.1016/j.vph.2024.107443

Daniel Wong , Hongyu Qiu

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引用次数: 0

摘要

血清反应因子（SRF）是一种关键的调控转录因子，广泛表达于各种细胞类型，对动物的生存至关重要。SRF 活性过高与心血管疾病、癌症和神经退行性疾病等各种病理状况和疾病有关，因此抑制 SRF 活性过高是一种可行的治疗策略。本综述总结了发现和开发 SRF 抑制剂的最新进展、其调控机制和分子基础。这些见解加深了我们对当前治疗潜力的理解，为治疗与 SRF 过度活跃相关疾病的新方法铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

New insights into the pharmacological inhibition of SRF activity: Key inhibitory targets and mechanisms

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New insights into the pharmacological inhibition of SRF activity: Key inhibitory targets and mechanisms

Serum Response Factor (SRF) is a critical regulatory transcription factor widely expressed across cell types and is essential for animal survival. Excessive SRF activity has been linked to various pathological conditions and diseases, including cardiovascular diseases, cancers and neurodegenerative disorders, making the inhibition of SRF hyperactivity a promising therapeutic strategy. This review summarizes recent advancements in the discovery and development of SRF inhibitors, their regulatory mechanisms, and their respective molecular foundations. These insights deepen our understanding of current therapeutic potentials, paving the way for novel approaches to treat diseases associated with SRF hyperactivity.

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来源期刊

Vascular pharmacology 医学-药学

CiteScore

6.60

自引率

2.50%

发文量

153

审稿时长

31 days

期刊介绍： Vascular Pharmacology publishes papers, which contains results of all aspects of biology and pharmacology of the vascular system. Papers are encouraged in basic, translational and clinical aspects of Vascular Biology and Pharmacology, utilizing approaches ranging from molecular biology to integrative physiology. All papers are in English. The Journal publishes review articles which include vascular aspects of thrombosis, inflammation, cell signalling, atherosclerosis, and lipid metabolism.