长期眼压升高的小鼠初级视皮层中的神经突触和树突棘被消除。

IF 5.9 2区 医学 Q2 CELL BIOLOGY
Neural Regeneration Research Pub Date : 2026-03-01 Epub Date: 2024-11-13 DOI:10.4103/NRR.NRR-D-24-00394
Xinyi Zhang, Deling Li, Weiting Zeng, Yiru Huang, Zongyi Zhan, Yuning Zhang, Qinyuan Hu, Lianyan Huang, Minbin Yu
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引用次数: 0

摘要

突触可塑性对维持中枢神经系统的神经元功能至关重要,也是神经退行性疾病影响的重要指标。青光眼直接损害视网膜神经节细胞及其轴突,导致轴突运输失调,继而对视觉系统的前端或后端造成二次损害。因此,最近的证据表明,青光眼是一种中枢神经系统退行性疾病,会对整个视觉通路造成损害。然而,青光眼对初级视觉皮层突触可塑性的影响仍不清楚。在这项研究中,我们通过向一只眼睛的前房注射磁性微珠,建立了单侧慢性眼压过高的小鼠模型。我们发现,慢性眼压升高 4 周后,患眼对侧大脑上丘和外侧膝状体区域的神经元体变小。与此同时,神经胶质细胞活化,炎症因子表达增加。眼压升高 8 周后,我们观察到患眼对侧初级视皮层的兴奋性和抑制性突触、树突棘数量减少,胶质细胞活化。这些研究结果表明,青光眼不仅会直接损伤视网膜,还会诱导初级视皮层中突触和树突棘的改变,从而为青光眼的发病机制提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synapses and dendritic spines are eliminated in the primary visual cortex of mice subjected to chronic intraocular pressure elevation.

JOURNAL/nrgr/04.03/01300535-202603000-00046/figure1/v/2025-06-16T082406Z/r/image-tiff Synaptic plasticity is essential for maintaining neuronal function in the central nervous system and serves as a critical indicator of the effects of neurodegenerative disease. Glaucoma directly impairs retinal ganglion cells and their axons, leading to axonal transport dysfuntion, subsequently causing secondary damage to anterior or posterior ends of the visual system. Accordingly, recent evidence indicates that glaucoma is a degenerative disease of the central nervous system that causes damage throughout the visual pathway. However, the effects of glaucoma on synaptic plasticity in the primary visual cortex remain unclear. In this study, we established a mouse model of unilateral chronic ocular hypertension by injecting magnetic microbeads into the anterior chamber of one eye. We found that, after 4 weeks of chronic ocular hypertension, the neuronal somas were smaller in the superior colliculus and lateral geniculate body regions of the brain contralateral to the affected eye. This was accompanied by glial cell activation and increased expression of inflammatory factors. After 8 weeks of ocular hypertension, we observed a reduction in the number of excitatory and inhibitory synapses, dendritic spines, and activation of glial cells in the primary visual cortex contralateral to the affected eye. These findings suggest that glaucoma not only directly damages the retina but also induces alterations in synapses and dendritic spines in the primary visual cortex, providing new insights into the pathogenesis of glaucoma.

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来源期刊
Neural Regeneration Research
Neural Regeneration Research CELL BIOLOGY-NEUROSCIENCES
CiteScore
8.00
自引率
9.80%
发文量
515
审稿时长
1.0 months
期刊介绍: Neural Regeneration Research (NRR) is the Open Access journal specializing in neural regeneration and indexed by SCI-E and PubMed. The journal is committed to publishing articles on basic pathobiology of injury, repair and protection to the nervous system, while considering preclinical and clinical trials targeted at improving traumatically injuried patients and patients with neurodegenerative diseases.
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