真菌对癌症发生、发展和治疗反应的影响

IF 12.5 1区 医学 Q1 ONCOLOGY
Hazrat Bilal, Muhammad Nadeem Khan, Sabir Khan, Muhammad Shafiq, Wenjie Fang, Yuebin Zeng, Yangzhong Guo, Xiaohui Li, Bing Zhao, Qiao-Li Lv, Bin Xu
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引用次数: 0

摘要

真菌菌群失调越来越被认为是癌症的一个关键因素,它影响着肿瘤的发生、发展和治疗效果。这篇综述探讨了真菌在致癌过程中的作用,重点关注免疫调节、炎症诱导、肿瘤微环境重塑和王国间相互作用等机制。真菌代谢产物参与肿瘤发生,抗真菌药物可与抗癌药物相互作用,包括引起潜在的不良反应和影响免疫反应。此外,真菌生物群图谱有可能成为诊断和预后的生物标志物,强调了其临床相关性。真菌与癌症疗法之间的相互作用会影响耐药性、疗效以及与靶向疗法相关的侵袭性真菌感染风险。最后,在癌症治疗中调节真菌生物群的新策略是改善患者预后的有希望的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fungal Influences on Cancer Initiation, Progression, and Response to Treatment.

Fungal dysbiosis is increasingly recognized as a key factor in cancer, influencing tumor initiation, progression, and treatment outcomes. This review explores the role of fungi in carcinogenesis, with a focus on mechanisms such as immunomodulation, inflammation induction, tumor microenvironment remodeling, and interkingdom interactions. Fungal metabolites are involved in oncogenesis, and antifungals can interact with anticancer drug, including eliciting potential adverse effects and influencing immune responses. Furthermore, mycobiota profiles have potential as diagnostic and prognostic biomarkers, emphasizing their clinical relevance. The interplay between fungi and cancer therapies can impact drug resistance, therapeutic efficacy, and risk of invasive fungal infections associated with targeted therapies. Finally, emerging strategies for modulating mycobiota in cancer care are promising approaches to improve patient outcomes.

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来源期刊
Cancer research
Cancer research 医学-肿瘤学
CiteScore
16.10
自引率
0.90%
发文量
7677
审稿时长
2.5 months
期刊介绍: Cancer Research, published by the American Association for Cancer Research (AACR), is a journal that focuses on impactful original studies, reviews, and opinion pieces relevant to the broad cancer research community. Manuscripts that present conceptual or technological advances leading to insights into cancer biology are particularly sought after. The journal also places emphasis on convergence science, which involves bridging multiple distinct areas of cancer research. With primary subsections including Cancer Biology, Cancer Immunology, Cancer Metabolism and Molecular Mechanisms, Translational Cancer Biology, Cancer Landscapes, and Convergence Science, Cancer Research has a comprehensive scope. It is published twice a month and has one volume per year, with a print ISSN of 0008-5472 and an online ISSN of 1538-7445. Cancer Research is abstracted and/or indexed in various databases and platforms, including BIOSIS Previews (R) Database, MEDLINE, Current Contents/Life Sciences, Current Contents/Clinical Medicine, Science Citation Index, Scopus, and Web of Science.
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