Roshan A. Ananda MD, Bethlehem Solomon MPhil, Kausik K. Ray FMedSci
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The primary outcome was severity of ASI analysed using multivariate-adjusted linear regression.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Of 162 590 participants, 42.5% were overweight and 24.4% were obese. Within the normal BMI strata, 50.7% had ≥1 metabolic abnormality. Compared to individuals with normal BMI and no metabolic abnormality (reference group), increased BMI or metabolic abnormalities were similarly associated with higher ASI: normal BMI with metabolic abnormalities (adjusted β-coefficient and 95% CI, 0.35; 0.30–0.40); overweight without metabolic abnormalities (0.32; 0.26–0.37). Individuals with obesity and no metabolic abnormality had higher ASI (0.65; 0.57–0.74) but was lower than individuals with overweight and metabolic abnormalities (0.80; 0.75–0.84). Individuals with obesity and metabolic abnormalities had the highest ASI (1.07; 1.02–1.12) among all six metabolic combinations, <i>p</i> < 0.001 for each versus reference group. Sensitivity analysis suggested higher ASI with increasing number of metabolic abnormalities within BMI categories and higher ASI in the presence of abdominal obesity within metabolic categories.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Excess adiposity and metabolic abnormalities are independently associated with increased arterial stiffness to a similar degree, suggesting that metabolically healthy individuals with overweight and obesity are not benign groups. This reinforces the need to prevent excess adiposity and consider primary prevention strategies even before metabolic abnormalities emerge.</p>\n </section>\n </div>","PeriodicalId":158,"journal":{"name":"Diabetes, Obesity & Metabolism","volume":"27 2","pages":"899-910"},"PeriodicalIF":5.4000,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dom.16090","citationCount":"0","resultStr":"{\"title\":\"Individual and joint associations of obesity and metabolic health parameters on arterial stiffness: Evidence from the UK Biobank\",\"authors\":\"Roshan A. Ananda MD, Bethlehem Solomon MPhil, Kausik K. 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引用次数: 0
摘要
目的：关于无代谢异常的过量脂肪是否反映了一种真正的良性表型，存在相互矛盾的证据。本研究评估了过量脂肪和代谢异常对动脉僵化的独立和联合影响：纳入英国生物数据库中 2006 年至 2010 年期间记录有体重指数（BMI）和动脉僵化指数（ASI）、无心血管疾病且非体重过轻（BMI 2）的参与者。主要结果是采用多变量调整线性回归分析 ASI 的严重程度：在 162 590 名参与者中，42.5% 超重，24.4% 肥胖。在体重指数正常的人群中，50.7%的人有≥1项代谢异常。与体重指数正常且无代谢异常的个体（参照组）相比，体重指数增加或代谢异常同样与较高的 ASI 相关：体重指数正常且有代谢异常（调整后的β系数和 95% CI，0.35；0.30-0.40）；超重且无代谢异常（0.32；0.26-0.37）。肥胖且无代谢异常者的 ASI 较高（0.65；0.57-0.74），但低于超重且有代谢异常者（0.80；0.75-0.84）。在所有六种代谢组合中，肥胖和代谢异常者的 ASI 最高（1.07；1.02-1.12），P 结论：过多的脂肪和代谢异常与动脉僵化的增加有相似程度的独立关联，这表明代谢健康的超重和肥胖者并非良性群体。这进一步说明，即使在代谢异常出现之前，也有必要预防过度肥胖，并考虑采取初级预防策略。
Individual and joint associations of obesity and metabolic health parameters on arterial stiffness: Evidence from the UK Biobank
Aims
There is conflicting evidence regarding whether excess adiposity without metabolic abnormalities reflects a truly benign phenotype. This study evaluated the independent and joint associations of the presence of excess adiposity and metabolic abnormalities on arterial stiffness.
Materials and Methods
Participants in UK Biobank with body mass index (BMI) and arterial stiffness index (ASI) recorded between 2006 and 2010, free from cardiovascular diseases and not underweight (BMI <18.5 kg/m2) were included. The primary outcome was severity of ASI analysed using multivariate-adjusted linear regression.
Results
Of 162 590 participants, 42.5% were overweight and 24.4% were obese. Within the normal BMI strata, 50.7% had ≥1 metabolic abnormality. Compared to individuals with normal BMI and no metabolic abnormality (reference group), increased BMI or metabolic abnormalities were similarly associated with higher ASI: normal BMI with metabolic abnormalities (adjusted β-coefficient and 95% CI, 0.35; 0.30–0.40); overweight without metabolic abnormalities (0.32; 0.26–0.37). Individuals with obesity and no metabolic abnormality had higher ASI (0.65; 0.57–0.74) but was lower than individuals with overweight and metabolic abnormalities (0.80; 0.75–0.84). Individuals with obesity and metabolic abnormalities had the highest ASI (1.07; 1.02–1.12) among all six metabolic combinations, p < 0.001 for each versus reference group. Sensitivity analysis suggested higher ASI with increasing number of metabolic abnormalities within BMI categories and higher ASI in the presence of abdominal obesity within metabolic categories.
Conclusions
Excess adiposity and metabolic abnormalities are independently associated with increased arterial stiffness to a similar degree, suggesting that metabolically healthy individuals with overweight and obesity are not benign groups. This reinforces the need to prevent excess adiposity and consider primary prevention strategies even before metabolic abnormalities emerge.
期刊介绍：
Diabetes, Obesity and Metabolism is primarily a journal of clinical and experimental pharmacology and therapeutics covering the interrelated areas of diabetes, obesity and metabolism. The journal prioritises high-quality original research that reports on the effects of new or existing therapies, including dietary, exercise and lifestyle (non-pharmacological) interventions, in any aspect of metabolic and endocrine disease, either in humans or animal and cellular systems. ‘Metabolism’ may relate to lipids, bone and drug metabolism, or broader aspects of endocrine dysfunction. Preclinical pharmacology, pharmacokinetic studies, meta-analyses and those addressing drug safety and tolerability are also highly suitable for publication in this journal. Original research may be published as a main paper or as a research letter.
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