João Paulo Lima Santos, Adriane M Soehner, Cecile D Ladouceur, Amelia Versace
{"title":"睡眠不足对儿童晚期和青少年早期白质发育的影响》（The Impact of Insufficient Sleep on White Matter Development in Late Childhood and Early Adolescence.","authors":"João Paulo Lima Santos, Adriane M Soehner, Cecile D Ladouceur, Amelia Versace","doi":"10.1016/j.jadohealth.2024.10.007","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Sleep is vital for brain development. Animal models have suggested that insufficient sleep affects axons and dendrites (known as neurites). However, the effects of insufficient sleep on neurites during brain development in humans remain understudied. Deriving neurite density index and orientation dispersion index (ODI) in a large sample (N = 1,016; 47.44% girls), we aimed to identify the effects of insufficient sleep on white matter development between late childhood (mean age [standard deviation] = 9.96 [0.62] years) and early adolescence (mean age [standard deviation] = 11.94 [0.64] years).</p><p><strong>Methods: </strong>Longitudinal Latent Class Analysis was used to derive longitudinal classes based on sleep duration from the Sleep Disturbance Scale for Children. The Child Behavior Checklist characterized behavioral (internalizing: anxious/depressed, withdrawn/depressed, somatic; externalizing: social, thought, attention, rule-breaking, and aggressive) problems. Regression analyses evaluated the effects of sleep classes on neurite density index, ODI, and standard tensor-based metrics (Fractional Anisotropy) changes over time, the focal or widespread effects along the tracts, and whether these effects were associated with behavioral problems.</p><p><strong>Results: </strong>Insufficient (<9 hours; N = 569) and sufficient sleep (>9 hours; N = 447) groups were identified. Insufficient sleep was associated with worsening fiber coherence (greater ODI) in most tracts, including cingulum bundle (F<sub>(1,982)</sub> = 9.22, p = .002, Q = 0.009), forceps minor (F<sub>(1,982)</sub> = 5.30, p = .021, Q = 0.026), and superior longitudinal fasciculus (F<sub>(1,982)</sub> = 7.41, p = .007, Q = 0.015). These effects were focal, particularly in the frontal portions of the tracts. No other metric was affected (p > .050). In addition, greater ODI in the cingulum bundle was associated with more anxious/depressed problems (β = 0.10, p = .012, Q = 0.036).</p><p><strong>Discussion: </strong>Our findings suggest that insufficient sleep during this sensitive period affects white matter development, which in turn affects internalizing problems. Our findings support the importance of promoting sufficient sleep during early adolescence.</p>","PeriodicalId":56278,"journal":{"name":"Journal of Adolescent Health","volume":" ","pages":""},"PeriodicalIF":5.5000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Impact of Insufficient Sleep on White Matter Development in Late Childhood and Early Adolescence.\",\"authors\":\"João Paulo Lima Santos, Adriane M Soehner, Cecile D Ladouceur, Amelia Versace\",\"doi\":\"10.1016/j.jadohealth.2024.10.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Sleep is vital for brain development. Animal models have suggested that insufficient sleep affects axons and dendrites (known as neurites). However, the effects of insufficient sleep on neurites during brain development in humans remain understudied. Deriving neurite density index and orientation dispersion index (ODI) in a large sample (N = 1,016; 47.44% girls), we aimed to identify the effects of insufficient sleep on white matter development between late childhood (mean age [standard deviation] = 9.96 [0.62] years) and early adolescence (mean age [standard deviation] = 11.94 [0.64] years).</p><p><strong>Methods: </strong>Longitudinal Latent Class Analysis was used to derive longitudinal classes based on sleep duration from the Sleep Disturbance Scale for Children. The Child Behavior Checklist characterized behavioral (internalizing: anxious/depressed, withdrawn/depressed, somatic; externalizing: social, thought, attention, rule-breaking, and aggressive) problems. Regression analyses evaluated the effects of sleep classes on neurite density index, ODI, and standard tensor-based metrics (Fractional Anisotropy) changes over time, the focal or widespread effects along the tracts, and whether these effects were associated with behavioral problems.</p><p><strong>Results: </strong>Insufficient (<9 hours; N = 569) and sufficient sleep (>9 hours; N = 447) groups were identified. Insufficient sleep was associated with worsening fiber coherence (greater ODI) in most tracts, including cingulum bundle (F<sub>(1,982)</sub> = 9.22, p = .002, Q = 0.009), forceps minor (F<sub>(1,982)</sub> = 5.30, p = .021, Q = 0.026), and superior longitudinal fasciculus (F<sub>(1,982)</sub> = 7.41, p = .007, Q = 0.015). These effects were focal, particularly in the frontal portions of the tracts. No other metric was affected (p > .050). In addition, greater ODI in the cingulum bundle was associated with more anxious/depressed problems (β = 0.10, p = .012, Q = 0.036).</p><p><strong>Discussion: </strong>Our findings suggest that insufficient sleep during this sensitive period affects white matter development, which in turn affects internalizing problems. 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The Impact of Insufficient Sleep on White Matter Development in Late Childhood and Early Adolescence.
Purpose: Sleep is vital for brain development. Animal models have suggested that insufficient sleep affects axons and dendrites (known as neurites). However, the effects of insufficient sleep on neurites during brain development in humans remain understudied. Deriving neurite density index and orientation dispersion index (ODI) in a large sample (N = 1,016; 47.44% girls), we aimed to identify the effects of insufficient sleep on white matter development between late childhood (mean age [standard deviation] = 9.96 [0.62] years) and early adolescence (mean age [standard deviation] = 11.94 [0.64] years).
Methods: Longitudinal Latent Class Analysis was used to derive longitudinal classes based on sleep duration from the Sleep Disturbance Scale for Children. The Child Behavior Checklist characterized behavioral (internalizing: anxious/depressed, withdrawn/depressed, somatic; externalizing: social, thought, attention, rule-breaking, and aggressive) problems. Regression analyses evaluated the effects of sleep classes on neurite density index, ODI, and standard tensor-based metrics (Fractional Anisotropy) changes over time, the focal or widespread effects along the tracts, and whether these effects were associated with behavioral problems.
Results: Insufficient (<9 hours; N = 569) and sufficient sleep (>9 hours; N = 447) groups were identified. Insufficient sleep was associated with worsening fiber coherence (greater ODI) in most tracts, including cingulum bundle (F(1,982) = 9.22, p = .002, Q = 0.009), forceps minor (F(1,982) = 5.30, p = .021, Q = 0.026), and superior longitudinal fasciculus (F(1,982) = 7.41, p = .007, Q = 0.015). These effects were focal, particularly in the frontal portions of the tracts. No other metric was affected (p > .050). In addition, greater ODI in the cingulum bundle was associated with more anxious/depressed problems (β = 0.10, p = .012, Q = 0.036).
Discussion: Our findings suggest that insufficient sleep during this sensitive period affects white matter development, which in turn affects internalizing problems. Our findings support the importance of promoting sufficient sleep during early adolescence.
期刊介绍：
The Journal of Adolescent Health is a scientific publication dedicated to enhancing the health and well-being of adolescents and young adults. Our Journal covers a broad range of research topics, spanning from the basic biological and behavioral sciences to public health and policy. We welcome a variety of contributions, including original research papers, concise reports, literature reviews, clinical case reports, opinion pieces, and letters to the editor. We encourage professionals from diverse disciplines such as Anthropology, Education, Ethics, Global Health, Health Services Research, Law, Medicine, Mental and Behavioral Health, Nursing, Nutrition, Psychology, Public Health and Policy, Social Work, Sociology, and Youth Development to share their expertise and contribute to our mission of promoting adolescent health. Moreover, we value the voices of young individuals, family and community members, and healthcare professionals, and encourage them to submit poetry, personal narratives, images, and other creative works that provide unique insights into the experiences of adolescents and young adults. By combining scientific peer-reviewed research with creative expressions, our Journal aims to create a comprehensive understanding of the challenges and opportunities in adolescent and young adult health.
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