S100A8 作为癌症转移的潜在治疗靶点。

IF 5.7 2区医学 Q1 Medicine

Cancer Science Pub Date : 2024-11-24 DOI:10.1111/cas.16407

Atsuko Deguchi, Yoshiro Maru

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引用次数: 0

摘要

转移是癌症相关死亡的主要原因。与肿瘤微环境的形成类似，转移前生态位也是在肿瘤细胞到达远处器官之前形成的。阐明转移前生态位形成的内在机制有助于建立有效的转移治疗靶点。我们的研究表明，原发性肿瘤利用内源性配体S100A8劫持Toll样受体4（TLR4）信号，在肺部建立转移前生态位。S100A8 不仅在免疫细胞中表达，在各类肿瘤细胞中也有表达。通过将 S100A8 作为治疗靶点，我们发现了至少三种多价 S100A8 抑制肽。在此，我们回顾了 S100A8 介导的 TLR4 信号转导对肿瘤的促进作用，并提出将 S100A8 作为侵袭性癌症的潜在治疗靶点。

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S100A8 as a potential therapeutic target for cancer metastasis.

Metastasis is a major cause of cancer-related deaths. Similar to the tumor microenvironment formation, the premetastatic niche develops in distant organs before the arrival of tumor cells. Elucidating the mechanism(s) underlying premetastatic niche formation could contribute to the establishment of effective therapeutic targets for metastasis. Our research indicates that primary tumors hijack Toll-like receptor 4 (TLR4) signaling to establish a premetastatic niche in the lungs by utilizing an endogenous ligand S100A8. S100A8 is expressed not only in immune cells but also in various types of tumor cells. By focusing on S100A8 as a therapeutic target, we identified at least three multivalent S100A8 inhibitory peptides. Here, we review the tumor-promoting role of S100A8-mediated TLR4 signaling and propose S100A8 as a potential therapeutic target for aggressive cancer.

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来源期刊

Cancer Science ONCOLOGY-

CiteScore

9.90

自引率

3.50%

发文量

406

审稿时长

17 weeks

期刊介绍： Cancer Science (formerly Japanese Journal of Cancer Research) is a monthly publication of the Japanese Cancer Association. First published in 1907, the Journal continues to publish original articles, editorials, and letters to the editor, describing original research in the fields of basic, translational and clinical cancer research. The Journal also accepts reports and case reports. Cancer Science aims to present highly significant and timely findings that have a significant clinical impact on oncologists or that may alter the disease concept of a tumor. The Journal will not publish case reports that describe a rare tumor or condition without new findings to be added to previous reports; combination of different tumors without new suggestive findings for oncological research; remarkable effect of already known treatments without suggestive data to explain the exceptional result. Review articles may also be published.