靶向神经元 PAS 结构域蛋白 2 和 KN motif/ankyrin 重复结构域 1：2 型糖尿病治疗的进展。

IF 4.2 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

World Journal of Diabetes Pub Date : 2024-11-15 DOI:10.4239/wjd.v15.i11.2173

Chun-Han Cheng, Wen-Rui Hao, Tzu-Hurng Cheng

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引用次数: 0

摘要

这篇社论总结了有关神经元 PAS 结构域蛋白 2 和 KN motif/ankyrin 重复结构域 1 在 2 型糖尿病（T2D）中作用的最新文献。我们强调了它们在β细胞功能障碍中的作用，探讨了它们作为治疗靶点的潜力，并讨论了对新治疗策略的影响。我们提供了有关基因调控和细胞机制的宝贵见解，这些见解与有针对性地治疗 T2D 息息相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Targeting neuronal PAS domain protein 2 and KN motif/ankyrin repeat domains 1: Advances in type 2 diabetes therapy.

This editorial summarizes the latest literature on the roles of neuronal PAS domain protein 2 and KN motif/ankyrin repeat domain 1 in type 2 diabetes (T2D). We highlight their involvement in β-cell dysfunction, explore their potential as therapeutic targets, and discuss the implications for new treatment strategies. We offer valuable insights into relevant gene regulation and cellular mechanisms relevant for the targeted management of T2D.

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来源期刊

World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

自引率

2.40%

发文量

909

期刊介绍： The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.