缺血性脑卒中后轻度认知功能障碍 (MCI) 患者认知障碍的演变:改善神经病学和精神病学医疗保健--延长寿命(IHCNP)研究的二次数据分析》。

IF 3.2 Q2 CLINICAL NEUROLOGY
Dragoș-Cătălin Jianu, Ligia Petrica, Traian Flavius Dan, Georgiana Munteanu, Bianca Bora, Sergiu Florin Arnăutu, Sorin Ursoniu, Diana Chira, Ștefan Strilciuc, Cristian Falup-Pecurariu, Dafin Fior Mureșanu
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引用次数: 0

摘要

研究背景改善神经病学和精神病学的医疗保健--延长生命(IHCNP)研究是一项为期 18 个月的前瞻性、观察性、非干预性研究,主要针对缺血性中风后轻度认知障碍(MCI)患者:我们对 IHCNP 数据进行了二次分析,旨在记录该患者群体 MCI 的进展情况:共招募了 100 名来自罗马尼亚的患者,所有患者都接受了认知评估,评估方法包括迷你精神状态检查 (MMSE)、蒙特利尔认知评估 (MoCA) 和雷氏听觉言语学习测试 (RAVLT)。临床评估也是研究的一部分。研究记录了基线认知评分,随后的随访记录了认知随时间的变化:结果:基线认知评分显示患者存在轻度认知障碍,MMSE 平均值为 25.41,MoCA 平均值为 23.27,RAVLT 平均值为 33.63。研究结束时,患者的认知能力明显下降,MMSE评分下降了8.7%,MoCA评分下降了10.0%,RAVLT评分下降了29.5%(所有指标的P < 0.0001),这反映了卒中后MCI的渐进性:这些发现强调了早期诊断和干预对缓解脑卒中后患者认知能力下降的重要性。该研究强调了对认知能力进行持续监测的必要性,以改善患者的预后并有效控制 MCI 的进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evolution of Cognitive Disorders in Patients with Mild Cognitive Impairment (MCI) After Ischemic Stroke: Secondary Data Analysis from the Improved Health Care in Neurology and Psychiatry-Longer Life (IHCNP) Study.

Background: The Improved Health Care in Neurology and Psychiatry-Longer Life (IHCNP) study was an 18-month prospective, observational, non-interventional research study focused on patients with mild cognitive impairment (MCI) following ischemic stroke.

Objectives: Our secondary analysis of the IHCNP data aimed to document the progression of MCI in this patient group.

Methods: A total of 100 patients from Romania were recruited, all of whom underwent cognitive assessments using the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Rey Auditory Verbal Learning Test (RAVLT). Clinical evaluations were also conducted as part of the study. Baseline cognitive scores were recorded, and subsequent follow-ups documented cognitive changes over time.

Results: At baseline, cognitive scores indicated mild impairment, with averages of MMSE 25.41, MoCA 23.27, and RAVLT 33.63. By the end of the study, patients exhibited a significant cognitive decline, with MMSE scores dropping by 8.7%, MoCA by 10.0%, and RAVLT by 29.5% (p < 0.0001 for all measures), reflecting the progressive nature of MCI post-stroke.

Conclusions: These findings highlight the importance of early diagnosis and intervention to mitigate cognitive decline in post-stroke patients. The study underscores the need for ongoing cognitive monitoring to improve patient outcomes and manage MCI progression effectively.

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来源期刊
Neurology International
Neurology International CLINICAL NEUROLOGY-
CiteScore
3.70
自引率
3.30%
发文量
69
审稿时长
11 weeks
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