Natalie Anne Bebbington, Lone Lange Østergård, Kenneth Boye Christensen, Paw Christian Holdgaard
{"title":"利用锡滤波器降低 PET-CT 定位/特征级图像质量的 CT 辐射剂量：一项模型研究。","authors":"Natalie Anne Bebbington, Lone Lange Østergård, Kenneth Boye Christensen, Paw Christian Holdgaard","doi":"10.1186/s40658-024-00703-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The tin filter has allowed radiation dose reduction in some standalone diagnostic computed tomography (CT) applications. Yet, 'low-dose' CT scans are commonly used in positron emission tomography (PET)-CT for lesion localisation/characterisation (L/C), with higher noise tolerated. Thus, dose reductions permissible with the tin filter at this image quality level may differ. The aim was to determine the level of CT dose reduction permitted with the tin filter in PET-CT, for comparable image quality to the clinical reference standard (CRS) L/C CT images acquired with standard filtration.</p><p><strong>Materials and methods: </strong>A whole-body CT phantom was scanned with standard filtration in CRS protocols, using 120 kV with 20mAs-ref for bone L/C (used in <sup>18</sup>F-Sodium Fluoride (NaF) PET-CT) and 40mAs-ref for soft tissue L/C (used in <sup>18</sup>F-Fluorodeoxyglucose (FDG) PET-CT), followed by tin filter scans at 100 kV (Sn100kV) and 140 kV (Sn140kV) with a range of mAs settings. For each scan, effective dose (ED) in an equivalent-sized patient was calculated, and image quality determined in 5 different tissues through quantitative (contrast-to-noise ratio) and qualitative (visual) analyses. The relative dose reductions which could be achieved with the tin filter for comparable image quality to CRS images were calculated.</p><p><strong>Results: </strong>Quantitative analysis demonstrated dose savings of 50-76% in bone, 27-51% in lung and 8-61% in soft tissue with use of the tin filter at Sn100kV. Qualitative analysis demonstrated dose reductions using Sn100kV in general agreement with the dose reductions indicated by quantitative analysis. Overall, CT dose reductions of around 85% were indicated for NaF bone PET-CT, allowing whole-body CT at just 0.2mSv ED, and a 30-40% CT dose reduction for FDG PET-CT using Sn100kV (1.7-2.0mSv), providing comparable image quality to current CRS images with standard filtration. Sn140kV demonstrated limited value in CT dose reduction.</p><p><strong>Conclusions: </strong>Large CT dose reductions can be made using the tin filter at Sn100kV, when imaging bone, lung and soft tissue at L/C level CT image quality in PET-CT. As well as reducing the risk of inducing a cancer in later life, such dose reductions may also impact PET-CT practice, such as justifying cross-sectional over planar imaging or justifying PET-CT in younger patients.</p>","PeriodicalId":11559,"journal":{"name":"EJNMMI Physics","volume":"11 1","pages":"100"},"PeriodicalIF":3.0000,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589033/pdf/","citationCount":"0","resultStr":"{\"title\":\"CT radiation dose reduction with tin filter for localisation/characterisation level image quality in PET-CT: a phantom study.\",\"authors\":\"Natalie Anne Bebbington, Lone Lange Østergård, Kenneth Boye Christensen, Paw Christian Holdgaard\",\"doi\":\"10.1186/s40658-024-00703-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The tin filter has allowed radiation dose reduction in some standalone diagnostic computed tomography (CT) applications. Yet, 'low-dose' CT scans are commonly used in positron emission tomography (PET)-CT for lesion localisation/characterisation (L/C), with higher noise tolerated. Thus, dose reductions permissible with the tin filter at this image quality level may differ. The aim was to determine the level of CT dose reduction permitted with the tin filter in PET-CT, for comparable image quality to the clinical reference standard (CRS) L/C CT images acquired with standard filtration.</p><p><strong>Materials and methods: </strong>A whole-body CT phantom was scanned with standard filtration in CRS protocols, using 120 kV with 20mAs-ref for bone L/C (used in <sup>18</sup>F-Sodium Fluoride (NaF) PET-CT) and 40mAs-ref for soft tissue L/C (used in <sup>18</sup>F-Fluorodeoxyglucose (FDG) PET-CT), followed by tin filter scans at 100 kV (Sn100kV) and 140 kV (Sn140kV) with a range of mAs settings. For each scan, effective dose (ED) in an equivalent-sized patient was calculated, and image quality determined in 5 different tissues through quantitative (contrast-to-noise ratio) and qualitative (visual) analyses. The relative dose reductions which could be achieved with the tin filter for comparable image quality to CRS images were calculated.</p><p><strong>Results: </strong>Quantitative analysis demonstrated dose savings of 50-76% in bone, 27-51% in lung and 8-61% in soft tissue with use of the tin filter at Sn100kV. Qualitative analysis demonstrated dose reductions using Sn100kV in general agreement with the dose reductions indicated by quantitative analysis. Overall, CT dose reductions of around 85% were indicated for NaF bone PET-CT, allowing whole-body CT at just 0.2mSv ED, and a 30-40% CT dose reduction for FDG PET-CT using Sn100kV (1.7-2.0mSv), providing comparable image quality to current CRS images with standard filtration. Sn140kV demonstrated limited value in CT dose reduction.</p><p><strong>Conclusions: </strong>Large CT dose reductions can be made using the tin filter at Sn100kV, when imaging bone, lung and soft tissue at L/C level CT image quality in PET-CT. As well as reducing the risk of inducing a cancer in later life, such dose reductions may also impact PET-CT practice, such as justifying cross-sectional over planar imaging or justifying PET-CT in younger patients.</p>\",\"PeriodicalId\":11559,\"journal\":{\"name\":\"EJNMMI Physics\",\"volume\":\"11 1\",\"pages\":\"100\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2024-11-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589033/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"EJNMMI Physics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s40658-024-00703-6\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"EJNMMI Physics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s40658-024-00703-6","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
CT radiation dose reduction with tin filter for localisation/characterisation level image quality in PET-CT: a phantom study.
Background: The tin filter has allowed radiation dose reduction in some standalone diagnostic computed tomography (CT) applications. Yet, 'low-dose' CT scans are commonly used in positron emission tomography (PET)-CT for lesion localisation/characterisation (L/C), with higher noise tolerated. Thus, dose reductions permissible with the tin filter at this image quality level may differ. The aim was to determine the level of CT dose reduction permitted with the tin filter in PET-CT, for comparable image quality to the clinical reference standard (CRS) L/C CT images acquired with standard filtration.
Materials and methods: A whole-body CT phantom was scanned with standard filtration in CRS protocols, using 120 kV with 20mAs-ref for bone L/C (used in 18F-Sodium Fluoride (NaF) PET-CT) and 40mAs-ref for soft tissue L/C (used in 18F-Fluorodeoxyglucose (FDG) PET-CT), followed by tin filter scans at 100 kV (Sn100kV) and 140 kV (Sn140kV) with a range of mAs settings. For each scan, effective dose (ED) in an equivalent-sized patient was calculated, and image quality determined in 5 different tissues through quantitative (contrast-to-noise ratio) and qualitative (visual) analyses. The relative dose reductions which could be achieved with the tin filter for comparable image quality to CRS images were calculated.
Results: Quantitative analysis demonstrated dose savings of 50-76% in bone, 27-51% in lung and 8-61% in soft tissue with use of the tin filter at Sn100kV. Qualitative analysis demonstrated dose reductions using Sn100kV in general agreement with the dose reductions indicated by quantitative analysis. Overall, CT dose reductions of around 85% were indicated for NaF bone PET-CT, allowing whole-body CT at just 0.2mSv ED, and a 30-40% CT dose reduction for FDG PET-CT using Sn100kV (1.7-2.0mSv), providing comparable image quality to current CRS images with standard filtration. Sn140kV demonstrated limited value in CT dose reduction.
Conclusions: Large CT dose reductions can be made using the tin filter at Sn100kV, when imaging bone, lung and soft tissue at L/C level CT image quality in PET-CT. As well as reducing the risk of inducing a cancer in later life, such dose reductions may also impact PET-CT practice, such as justifying cross-sectional over planar imaging or justifying PET-CT in younger patients.
期刊介绍：
EJNMMI Physics is an international platform for scientists, users and adopters of nuclear medicine with a particular interest in physics matters. As a companion journal to the European Journal of Nuclear Medicine and Molecular Imaging, this journal has a multi-disciplinary approach and welcomes original materials and studies with a focus on applied physics and mathematics as well as imaging systems engineering and prototyping in nuclear medicine. This includes physics-driven approaches or algorithms supported by physics that foster early clinical adoption of nuclear medicine imaging and therapy.
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