Dudari B. Burueva , Sergey V. Sviyazov , Nikita V. Chukanov , Nazim R. Mustafin , Oleg G. Salnikov , Eduard Y. Chekmenev , Kirill V. Kovtunov , Igor V. Koptyug
{"title":"使用对氢使[13C]甲酸盐超极化","authors":"Dudari B. Burueva , Sergey V. Sviyazov , Nikita V. Chukanov , Nazim R. Mustafin , Oleg G. Salnikov , Eduard Y. Chekmenev , Kirill V. Kovtunov , Igor V. Koptyug","doi":"10.1016/j.jmro.2024.100176","DOIUrl":null,"url":null,"abstract":"<div><div>Sodium [<sup>13</sup>C]formate was successfully hyperpolarized using parahydrogen-induced polarization by means of side-arm hydrogenation (PHIP-SAH). Allyl [<sup>13</sup>C]formate was hyperpolarized using homogeneous hydrogenation of the corresponding unsaturated precursor (propargyl [<sup>13</sup>C]formate) in acetone-d<sub>6</sub> with parahydrogen. The observed proton polarization was estimated as 16.6 ± 0.6 % while achieving 80 % chemical conversion. The <sup>1</sup>H-to-<sup>13</sup>C polarization transfer was performed using magnetic field cycling. The highest observed polarization for <sup>13</sup>C nuclei was estimated as 1.7 ± 0.2 % and was obtained at 250 nT polarization transfer magnetic field. We demonstrate that the <sup>13</sup>C hyperpolarization is retained during the hydrolysis of allyl [<sup>13</sup>C]formate and hyperpolarized sodium [<sup>13</sup>C]formate was produced with P<sub>13C</sub> of 0.4 ± 0.1 %.</div></div>","PeriodicalId":365,"journal":{"name":"Journal of Magnetic Resonance Open","volume":"21 ","pages":"Article 100176"},"PeriodicalIF":2.6240,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hyperpolarization of [13C]formate using parahydrogen\",\"authors\":\"Dudari B. Burueva , Sergey V. Sviyazov , Nikita V. Chukanov , Nazim R. Mustafin , Oleg G. Salnikov , Eduard Y. Chekmenev , Kirill V. Kovtunov , Igor V. Koptyug\",\"doi\":\"10.1016/j.jmro.2024.100176\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Sodium [<sup>13</sup>C]formate was successfully hyperpolarized using parahydrogen-induced polarization by means of side-arm hydrogenation (PHIP-SAH). Allyl [<sup>13</sup>C]formate was hyperpolarized using homogeneous hydrogenation of the corresponding unsaturated precursor (propargyl [<sup>13</sup>C]formate) in acetone-d<sub>6</sub> with parahydrogen. The observed proton polarization was estimated as 16.6 ± 0.6 % while achieving 80 % chemical conversion. The <sup>1</sup>H-to-<sup>13</sup>C polarization transfer was performed using magnetic field cycling. The highest observed polarization for <sup>13</sup>C nuclei was estimated as 1.7 ± 0.2 % and was obtained at 250 nT polarization transfer magnetic field. We demonstrate that the <sup>13</sup>C hyperpolarization is retained during the hydrolysis of allyl [<sup>13</sup>C]formate and hyperpolarized sodium [<sup>13</sup>C]formate was produced with P<sub>13C</sub> of 0.4 ± 0.1 %.</div></div>\",\"PeriodicalId\":365,\"journal\":{\"name\":\"Journal of Magnetic Resonance Open\",\"volume\":\"21 \",\"pages\":\"Article 100176\"},\"PeriodicalIF\":2.6240,\"publicationDate\":\"2024-11-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Magnetic Resonance Open\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666441024000311\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Magnetic Resonance Open","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666441024000311","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Hyperpolarization of [13C]formate using parahydrogen
Sodium [13C]formate was successfully hyperpolarized using parahydrogen-induced polarization by means of side-arm hydrogenation (PHIP-SAH). Allyl [13C]formate was hyperpolarized using homogeneous hydrogenation of the corresponding unsaturated precursor (propargyl [13C]formate) in acetone-d6 with parahydrogen. The observed proton polarization was estimated as 16.6 ± 0.6 % while achieving 80 % chemical conversion. The 1H-to-13C polarization transfer was performed using magnetic field cycling. The highest observed polarization for 13C nuclei was estimated as 1.7 ± 0.2 % and was obtained at 250 nT polarization transfer magnetic field. We demonstrate that the 13C hyperpolarization is retained during the hydrolysis of allyl [13C]formate and hyperpolarized sodium [13C]formate was produced with P13C of 0.4 ± 0.1 %.
![Hyperpolarization of [13C]formate using parahydrogen](https://img.booksci.cn/booksciimg/2024-11/99295468321763145138.jpg)
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