Mohamed Allouche , Areej M.A. Al-Shomrani , Fay S. Bagilb , Refah F. Alajmi , May Nasser Bin-Jumah , Haifa A. Alqhtani , Octavian Pacioglu , Amor Hedfi , Omar H. Abd-Elkader , Fehmi Boufahja
{"title":"厄贝沙坦和洛沙坦对自由生活的海洋线虫具有生态毒性吗?来自分类学和功能特征的反应要素","authors":"Mohamed Allouche , Areej M.A. Al-Shomrani , Fay S. Bagilb , Refah F. Alajmi , May Nasser Bin-Jumah , Haifa A. Alqhtani , Octavian Pacioglu , Amor Hedfi , Omar H. Abd-Elkader , Fehmi Boufahja","doi":"10.1016/j.rsma.2024.103934","DOIUrl":null,"url":null,"abstract":"<div><div>The Angiotensin II receptor antagonists (ARA II) are primarily eliminated in domestic effluent and commonly observed in conventional wastewater from sewage plants and rivers that receive run-off from treatment facilities. Nevertheless, ARA II medications show low elimination efficiencies in municipal wastewater treatment facilities, suggesting possible harmful effects for aquatic life. In the current study, individual and combined treatments (187.5–900 ng/L) of two ARA II, losartan and irbesartan, were applied for one month to marine nematodes. The results highlighted significant decreases in the relative abundance of epistratum feeding groups, characterized by a spiral amphid shape, elongated/filiform tail shape, and c-p3 life history type, especially in the assemblages exposed to the highest concentrations and mixtures. The results also emphasized that losartan is more toxic compared to irbesartan, with antagonism interactions between both drugs. Another conclusion was that <em>Longicyatholaimus longicaudatus</em> and <em>Marylynnia puncticaudata</em> were sensitive to ARA II contamination, whereas the genera <em>Theristus</em>, <em>Halalaimus</em>, and <em>Sabatieria</em> species were tolerant.</div></div>","PeriodicalId":21070,"journal":{"name":"Regional Studies in Marine Science","volume":"81 ","pages":"Article 103934"},"PeriodicalIF":2.1000,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Are irbesartan and losartan ecotoxic for free-living marine nematodes? Response elements from taxonomic and functional features\",\"authors\":\"Mohamed Allouche , Areej M.A. Al-Shomrani , Fay S. Bagilb , Refah F. Alajmi , May Nasser Bin-Jumah , Haifa A. Alqhtani , Octavian Pacioglu , Amor Hedfi , Omar H. Abd-Elkader , Fehmi Boufahja\",\"doi\":\"10.1016/j.rsma.2024.103934\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The Angiotensin II receptor antagonists (ARA II) are primarily eliminated in domestic effluent and commonly observed in conventional wastewater from sewage plants and rivers that receive run-off from treatment facilities. Nevertheless, ARA II medications show low elimination efficiencies in municipal wastewater treatment facilities, suggesting possible harmful effects for aquatic life. In the current study, individual and combined treatments (187.5–900 ng/L) of two ARA II, losartan and irbesartan, were applied for one month to marine nematodes. The results highlighted significant decreases in the relative abundance of epistratum feeding groups, characterized by a spiral amphid shape, elongated/filiform tail shape, and c-p3 life history type, especially in the assemblages exposed to the highest concentrations and mixtures. The results also emphasized that losartan is more toxic compared to irbesartan, with antagonism interactions between both drugs. Another conclusion was that <em>Longicyatholaimus longicaudatus</em> and <em>Marylynnia puncticaudata</em> were sensitive to ARA II contamination, whereas the genera <em>Theristus</em>, <em>Halalaimus</em>, and <em>Sabatieria</em> species were tolerant.</div></div>\",\"PeriodicalId\":21070,\"journal\":{\"name\":\"Regional Studies in Marine Science\",\"volume\":\"81 \",\"pages\":\"Article 103934\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-11-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Regional Studies in Marine Science\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S235248552400567X\",\"RegionNum\":4,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Regional Studies in Marine Science","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S235248552400567X","RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ECOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
血管紧张素 II 受体拮抗剂(ARA II)主要在生活污水中消除,在污水处理厂的常规废水和接收处理设施径流的河流中也能常见到。然而,ARA II 药物在城市污水处理设施中的消除效率很低,这表明可能会对水生生物产生有害影响。在目前的研究中,对海洋线虫施用两种 ARA II 药物(洛沙坦和厄贝沙坦,187.5-900 纳克/升),分别和联合处理(187.5-900 纳克/升)一个月。结果表明,以螺旋形两栖类、细长/丝状尾形和 c-p3 生活史类型为特征的epistratum 摄食群体的相对丰度明显下降,尤其是在暴露于最高浓度和混合物的群体中。研究结果还强调,与厄贝沙坦相比,洛沙坦的毒性更大,两种药物之间存在拮抗作用。另一个结论是,Longicyatholaimus longicaudatus 和 Marylynnia puncticaudata 对 ARA II 污染敏感,而 Theristus 属、Halalaimus 属和 Sabatieria 属物种则具有耐受性。
Are irbesartan and losartan ecotoxic for free-living marine nematodes? Response elements from taxonomic and functional features
The Angiotensin II receptor antagonists (ARA II) are primarily eliminated in domestic effluent and commonly observed in conventional wastewater from sewage plants and rivers that receive run-off from treatment facilities. Nevertheless, ARA II medications show low elimination efficiencies in municipal wastewater treatment facilities, suggesting possible harmful effects for aquatic life. In the current study, individual and combined treatments (187.5–900 ng/L) of two ARA II, losartan and irbesartan, were applied for one month to marine nematodes. The results highlighted significant decreases in the relative abundance of epistratum feeding groups, characterized by a spiral amphid shape, elongated/filiform tail shape, and c-p3 life history type, especially in the assemblages exposed to the highest concentrations and mixtures. The results also emphasized that losartan is more toxic compared to irbesartan, with antagonism interactions between both drugs. Another conclusion was that Longicyatholaimus longicaudatus and Marylynnia puncticaudata were sensitive to ARA II contamination, whereas the genera Theristus, Halalaimus, and Sabatieria species were tolerant.
期刊介绍:
REGIONAL STUDIES IN MARINE SCIENCE will publish scientifically sound papers on regional aspects of maritime and marine resources in estuaries, coastal zones, continental shelf, the seas and oceans.