钌基大环和希夫碱配合物作为重要的治疗药物：它们的设计、合成和最新前景

IF 2.4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Polyhedron Pub Date : 2024-11-17 DOI:10.1016/j.poly.2024.117309

Urmila Phageria , Sushama Kumari , Krishna Atal , Swati Bugalia

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引用次数: 0

摘要

大环和希夫碱配合物在化学和生命科学中的作用为研究人员提供了大量机会。在此，本综述将重点介绍钌基大环配合物的最新发展及其用途。如今，钌基大环配合物在抗氧化、抗癌、抗菌、催化、传感器、颜料、染料等众多领域都得到了广泛的应用。本研究结合了这些大环配体及其与钌配合物的建模和应用方面的创新，是化学、物理学和生物学领域的一次互动。可能是 Ru(II) 和 Ru(III) 复合物通过八面体键实现了更广泛的三维支架固定，这就为其生物底物的附着点多样性提供了更大的可能性。本研究还对这一主题进行了更广泛的概述，旨在强调配体设计、合成方法和有效应用方面的发展，特别是这些金属配合物在不同领域作为突出治疗药物的应用。此外，本研究还重点介绍了一些与同种金属的希夫碱配合物及其突出应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ruthenium-based macrocyclic and Schiff base complexes as prominent therapeutic agents: Their designing, synthesis and recent perspectives

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Ruthenium-based macrocyclic and Schiff base complexes as prominent therapeutic agents: Their designing, synthesis and recent perspectives

The role of macrocyclic and Schiff base complexes in chemistry and life sciences offers vast opportunities to the researchers. Herein, this review focuses on the recent developments in ruthenium-based macrocyclic complexes and their utilities. Nowadays, ruthenium-based macrocyclic complexes are substantially exploited in copious applications, such as antioxidant, anticancer, antimicrobial, catalysis, sensors, pigments, dyes, etc. are a few of them. This study combines innovations in modelling and employment of these macrocyclic ligands and their complexes with ruthenium that serves as an interaction between the fields of chemistry, physics and biology. Probably Ru(II) and Ru(III) complexes achieve a wider holder of a three-dimensional scaffold through octahedral bonding, which opens up the possibility for a greater level of site diversity for attaching to their biological substrates. This study also expresses a broader overview of the topic and aims to highlight developments in ligand designing, synthetic methods, and potent applications especially as prominent therapeutic agents of these metal complexes in diverse areas. Additionally, some of the Schiff bases complexes with the same metal are also highlighted with their prominent applications.

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来源期刊

Polyhedron 化学-晶体学

CiteScore

4.90

自引率

7.70%

发文量

515

审稿时长

2 months

期刊介绍： Polyhedron publishes original, fundamental, experimental and theoretical work of the highest quality in all the major areas of inorganic chemistry. This includes synthetic chemistry, coordination chemistry, organometallic chemistry, bioinorganic chemistry, and solid-state and materials chemistry. Papers should be significant pieces of work, and all new compounds must be appropriately characterized. The inclusion of single-crystal X-ray structural data is strongly encouraged, but papers reporting only the X-ray structure determination of a single compound will usually not be considered. Papers on solid-state or materials chemistry will be expected to have a significant molecular chemistry component (such as the synthesis and characterization of the molecular precursors and/or a systematic study of the use of different precursors or reaction conditions) or demonstrate a cutting-edge application (for example inorganic materials for energy applications). Papers dealing only with stability constants are not considered.