Melanie A. Kascoutas , Alison Sy-min Chang , Kiana E. Kawamura , Gabriela M. Bailey , Parker T. Morris , Elizabeth A. Borst , Lilliana H. Granados , Amanda K. Cook
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Tuneable, in situ-generated nickel-hydride alkene isomerisation catalyst†
A modular, operationally practical Ni(0)/silane alkene isomerisation system has been developed with air-tolerant reagents. An attractive feature of this method is the ability to rapidly screen a variety of N-heterocyclic carbene (NHC) ligands, enabling optimisation through ancillary ligand backbone modification for enhanced reactivity. This system is readily scalable (>1 g alkene) and tolerates a diverse array of functional groups in high E-selectivity, including aryl bromides, heterocycles, tertiary amines, and α,β-unsaturated amides. Preliminary mechanistic experiments support a Ni–H insertion/elimination pathway.
期刊介绍:
A multidisciplinary journal focusing on cutting edge research across all fundamental science and technological aspects of catalysis.
Editor-in-chief: Bert Weckhuysen
Impact factor: 5.0
Time to first decision (peer reviewed only): 31 days