多发性硬化症患者的 Epstein-Barr 核抗原 1 抗体指数升高。

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Multiple sclerosis and related disorders Pub Date : 2024-11-17 DOI:10.1016/j.msard.2024.106173

Rimsha Ali , Nicole Hartwig Trier , Gunnar Houen , Jette Lautrup Frederiksen

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引用次数: 0

摘要

背景：多发性硬化症（MS）是一种慢性中枢神经系统疾病：多发性硬化症（MS）是一种慢性中枢神经系统（CNS）疾病，可通过临床症状、磁共振成像和鞘内抗体合成增加的测量结果综合诊断。遗传和环境因素都会影响该病的发病，尤其是 Epstein-Barr 病毒（EBV）感染直接参与了多发性硬化症的发病。在这项开放性回顾性研究中，我们旨在探讨各种基于血清和脑脊液（CSF）的 EBV 抗体指标是否有助于多发性硬化症的诊断：方法：采用酶联免疫吸附法测定复发性多发性硬化症（RR）患者（n=61）（男：女28：33，平均40岁）、视神经炎患者（n=26）（男：女9：17，平均47岁）和健康对照（HCs）（n=15）（男：女8：7，平均43岁）血清和脑脊液中的EB病毒核抗原（EBNA）1 IgG浓度。将获得的 EBNA1 IgG 水平与总 IgG、白蛋白浓度、特异性抗体指数以及各种基于血清和脑脊液的指数等因素进行比较：结果：与HCs相比，RRMS患者血清和CSF中的EBNA1 IgG水平明显升高。CSF EBNA1 IgG 和基于特异性 CSF EBNA1 IgG 与 CSF 白蛋白或血清 EBNA1 IgG 与血清总 IgG 相关性的指数获得了最高的灵敏度，并补充了 IgG 指数和寡克隆带：这些研究结果表明，上述指标可作为现有指标的补充，有助于多发性硬化症的诊断。

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Epstein-Barr nuclear antigen 1 antibody-based indices are increased in patients with multiple sclerosis

Background

Multiple sclerosis (MS) is a chronic central nervous system (CNS) disease, which is diagnosed by a combination of clinical symptoms and magnetic resonance imaging and measurement of an increased intrathecal antibody synthesis. Genetic as well as environmental factors influence onset of the disease, where especially Epstein-Barr virus (EBV) infection is directly involved in MS development. In this open retrospective study, we aimed to elaborate whether various serum and cerebrospinal fluid (CSF)-based EBV antibody indices may aid in the diagnosis of MS.

Methods

Epstein-Barr nuclear antigen (EBNA)1 IgG concentrations in serum and CSF of relapsing-remitting (RR)MS patients (n=61) (M:F 28:33, average 40 years), optic neuritis patients (n=26) (M:F 9:17, average 47 years) and healthy controls (HCs) (n=15) (M:F 8:7, average 43 years) were determined by enzyme-linked immunosorbent assay. The obtained EBNA1 IgG levels were compared to factors such as total IgG, albumin concentrations, specific antibody index, and various serum- and CSF-based indices.

Results

Significantly elevated EBNA1 IgG levels were detected in serum and CSF of RRMS patients compared to HCs. CSF EBNA1 IgG and indices based on specific CSF EBNA1 IgG associated with CSF albumin or serum EBNA1 IgG associated with total serum IgG obtained the highest sensitivities and complemented the IgG index and oligoclonal bands.

Conclusion

These findings indicate that aforementioned indices may supplement existing indices and aid in the diagnosis of MS.

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来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.