疥疮的流行率和决定因素：全球系统回顾和荟萃分析。

IF 2.6 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Tropical Medicine & International Health Pub Date : 2024-12-01 Epub Date: 2024-11-22 DOI:10.1111/tmi.14058

Saptorshi Gupta, Simon Thornley, Arthur Morris, Gerhard Sundborn, Cameron Grant

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Odds ratios (ORs), risk of bias, subgroup analyses and meta-regression were used to describe variation in effect size and heterogeneity based on country-level demographic and economic variables.Results: Seventy studies yielded a pooled prevalence of 11.9% (95% confidence interval [CI]: 9.60-14.7) with substantial heterogeneity <math> <mrow> <mfenced> <mrow><msup><mi>I</mi> <mn>2</mn></msup> <mo>=</mo> <mn>100</mn> <mo>%</mo></mrow> <mrow><msup><mi>τ</mi> <mn>2</mn></msup> <mo>=</mo> <mn>1.04</mn></mrow> </mfenced> </mrow> </math> . Prevalence was highest in Oceania (17.9%; 95% CI: 13.9-22.8) compared to other regions. 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引用次数: 0

摘要

目标：疥疮是一种被忽视的皮肤病，对资源贫乏和过度拥挤国家的人影响极大。有关发病率和风险因素的全球数据十分有限。本文旨在估算疥疮的全球负担，并确定与之相关的风险：方法：访问数据库（PubMed、Scopus 和 Cochrane Reviews）以确定 2000 年至 2024 年间发表的有关疥疮流行率的研究。对研究结果进行汇总，以估算患病率，并找出解释研究间异质性的因素。研究使用了比值比（ORs）、偏倚风险、亚组分析和元回归来描述基于国家级人口和经济变量的效应大小和异质性的变化：70项研究得出的总患病率为11.9%（95%置信区间[CI]：9.60-14.7），异质性很高，I 2 = 100 % τ 2 = 1.04 $$ \left({I}^2=100\%;{\tau}^2=1.04\right) $$ 。与其他地区相比，大洋洲的患病率最高（17.9%；95% CI：13.9-22.8）。汇总的疥疮风险因素显示，人口和行为因素与疥疮有显著关联，包括与有瘙痒的家庭成员的接触史（OR 11.3; 95% CI 4.82-26.51; I 2 = 96 % $$ {I}^2=96\% $$ ; n = 7）、不使用肥皂（OR 3.41; 95% CI: 2.56-4.54; I 2 = 44 % $$ {I}^2=44\% $$ ; n = 7）、共床（OR 2.64; 95% CI: 1.50-4.63; I 2 = 76 % $$ {I}^2=76\% $$ ; n = 7），共用衣物（OR 2.52; 95% CI: 1.58-4.03; I 2 = 85 % $$ {I}^2=85\% $$ ; n = 7），不经常洗澡（OR 2.13; 95% CI: 1.41-3.22; I 2 = 77 % $$ {I}^2=77\% $$ ; n = 6），有宠物（OR 1.76; 95% CI: 1.08-2.87; I 2 = 84 % $$ {I}^2=84\% $$ ; n = 4）和男性（OR = 1.19; 95% CI: 1.04-1.37; I 2 = 83 % $$ {I}^2=83\% $$ ; n = 22）。社会经济因素与疥疮发病率没有令人信服的关联：结论：疥疮的流行与地理位置和行为因素有关，但与国家间的社会经济状况无关。除大规模用药外，还发现了一些风险因素，可将其纳入健康促进计划，以长期降低疥疮发病率并减少其后遗症。

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Prevalence and determinants of scabies: A global systematic review and meta-analysis.

Objectives: Scabies is a neglected skin disease that disproportionately affects people from resource poor and overcrowded countries. Global data on prevalence and risk factors are limited. This article aims to estimate the global burden of scabies and identifies the risks associated with it.

Methods: Databases (PubMed, Scopus and Cochrane Reviews) were accessed to identify studies of scabies prevalence published between 2000 and 2024. Results were pooled to estimate prevalence and identify factors, which explained between-study heterogeneity. Odds ratios (ORs), risk of bias, subgroup analyses and meta-regression were used to describe variation in effect size and heterogeneity based on country-level demographic and economic variables.

Results: Seventy studies yielded a pooled prevalence of 11.9% (95% confidence interval [CI]: 9.60-14.7) with substantial heterogeneity $(I^{2} = 100 %, τ^{2} = 1.04)$ . Prevalence was highest in Oceania (17.9%; 95% CI: 13.9-22.8) compared to other regions. Pooled risk factors for scabies showed significant associations for demographic and behavioural factors including contact history with household members with itch (OR 11.3; 95% CI 4.82-26.51; $I^{2} = 96 %$ ; n = 7), lack of soap use (OR 3.41; 95% CI: 2.56-4.54; $I^{2} = 44 %$ ; n = 7), bed-sharing (OR 2.64; 95% CI: 1.50-4.63; $I^{2} = 76 %$ ; n = 7), sharing of clothes (OR 2.52; 95% CI: 1.58-4.03; $I^{2} = 85 %$ ; n = 7), infrequent bathing (OR 2.13; 95% CI: 1.41-3.22; $I^{2} = 77 %$ ; n = 6), presence of pets (OR 1.76; 95% CI: 1.08-2.87; $I^{2} = 84 %$ ; n = 4) and being a male (OR = 1.19; 95% CI: 1.04-1.37; $I^{2} = 83 %$ ; n = 22). Socioeconomic factors were not convincingly associated with scabies prevalence.

Conclusion: Prevalence of scabies is associated with geographic location and behavioural factors, but not between-country socioeconomic status. In addition to mass drug administration, risk factors are identified which may be included in health promotion programmes to reduce scabies prevalence and its sequelae in the long term.

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来源期刊

Tropical Medicine & International Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.80

自引率

0.00%

发文量

129

审稿时长

6 months

期刊介绍： Tropical Medicine & International Health is published on behalf of the London School of Hygiene and Tropical Medicine, Swiss Tropical and Public Health Institute, Foundation Tropical Medicine and International Health, Belgian Institute of Tropical Medicine and Bernhard-Nocht-Institute for Tropical Medicine. Tropical Medicine & International Health is the official journal of the Federation of European Societies for Tropical Medicine and International Health (FESTMIH).