Heng Wei, Coskun Bilgi, Kellie Cao, Jon A Detterich, Niema M Pahlevan, Andrew L Cheng
{"title":"血液粘度建模对芳坦循环儿科患者计算流体动力学模拟的影响。","authors":"Heng Wei, Coskun Bilgi, Kellie Cao, Jon A Detterich, Niema M Pahlevan, Andrew L Cheng","doi":"10.1063/5.0236095","DOIUrl":null,"url":null,"abstract":"<p><p>For univentricular heart patients, the Fontan circulation presents a unique pathophysiology due to chronic non-pulsatile low-shear-rate pulmonary blood flow, where non-Newtonian effects are likely substantial. This study evaluates the influence of non-Newtonian behavior of blood on fluid dynamics and energetic efficiency in pediatric patient-specific models of the Fontan circulation. We used immersed boundary-lattice Boltzmann method simulations to compare Newtonian and non-Newtonian viscosity models. The study included models from twenty patients exhibiting a low cardiac output state (cardiac index of 2 L/min/m<sup>2</sup>). We quantified metrics of energy loss (indexed power loss and viscous dissipation), non-Newtonian importance factors, and hepatic flow distribution. We observed significant differences in flow structure between Newtonian and non-Newtonian models. Specifically, the non-Newtonian simulations demonstrated significantly higher local and average viscosity, corresponding to a higher non-Newtonian importance factor and larger energy loss. Hepatic flow distribution was also significantly different in a subset of patients. These findings suggest that non-Newtonian behavior contributes to flow structure and energetic inefficiency in the low cardiac output state of the Fontan circulation.</p>","PeriodicalId":20066,"journal":{"name":"Physics of Fluids","volume":"36 11","pages":"111911"},"PeriodicalIF":4.1000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577338/pdf/","citationCount":"0","resultStr":"{\"title\":\"The impact of blood viscosity modeling on computational fluid dynamic simulations of pediatric patients with Fontan circulation.\",\"authors\":\"Heng Wei, Coskun Bilgi, Kellie Cao, Jon A Detterich, Niema M Pahlevan, Andrew L Cheng\",\"doi\":\"10.1063/5.0236095\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>For univentricular heart patients, the Fontan circulation presents a unique pathophysiology due to chronic non-pulsatile low-shear-rate pulmonary blood flow, where non-Newtonian effects are likely substantial. This study evaluates the influence of non-Newtonian behavior of blood on fluid dynamics and energetic efficiency in pediatric patient-specific models of the Fontan circulation. We used immersed boundary-lattice Boltzmann method simulations to compare Newtonian and non-Newtonian viscosity models. The study included models from twenty patients exhibiting a low cardiac output state (cardiac index of 2 L/min/m<sup>2</sup>). We quantified metrics of energy loss (indexed power loss and viscous dissipation), non-Newtonian importance factors, and hepatic flow distribution. We observed significant differences in flow structure between Newtonian and non-Newtonian models. Specifically, the non-Newtonian simulations demonstrated significantly higher local and average viscosity, corresponding to a higher non-Newtonian importance factor and larger energy loss. Hepatic flow distribution was also significantly different in a subset of patients. These findings suggest that non-Newtonian behavior contributes to flow structure and energetic inefficiency in the low cardiac output state of the Fontan circulation.</p>\",\"PeriodicalId\":20066,\"journal\":{\"name\":\"Physics of Fluids\",\"volume\":\"36 11\",\"pages\":\"111911\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577338/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physics of Fluids\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1063/5.0236095\",\"RegionNum\":2,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/11/13 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"MECHANICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physics of Fluids","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1063/5.0236095","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/13 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"MECHANICS","Score":null,"Total":0}
The impact of blood viscosity modeling on computational fluid dynamic simulations of pediatric patients with Fontan circulation.
For univentricular heart patients, the Fontan circulation presents a unique pathophysiology due to chronic non-pulsatile low-shear-rate pulmonary blood flow, where non-Newtonian effects are likely substantial. This study evaluates the influence of non-Newtonian behavior of blood on fluid dynamics and energetic efficiency in pediatric patient-specific models of the Fontan circulation. We used immersed boundary-lattice Boltzmann method simulations to compare Newtonian and non-Newtonian viscosity models. The study included models from twenty patients exhibiting a low cardiac output state (cardiac index of 2 L/min/m2). We quantified metrics of energy loss (indexed power loss and viscous dissipation), non-Newtonian importance factors, and hepatic flow distribution. We observed significant differences in flow structure between Newtonian and non-Newtonian models. Specifically, the non-Newtonian simulations demonstrated significantly higher local and average viscosity, corresponding to a higher non-Newtonian importance factor and larger energy loss. Hepatic flow distribution was also significantly different in a subset of patients. These findings suggest that non-Newtonian behavior contributes to flow structure and energetic inefficiency in the low cardiac output state of the Fontan circulation.
期刊介绍:
Physics of Fluids (PoF) is a preeminent journal devoted to publishing original theoretical, computational, and experimental contributions to the understanding of the dynamics of gases, liquids, and complex or multiphase fluids. Topics published in PoF are diverse and reflect the most important subjects in fluid dynamics, including, but not limited to:
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