{"title":"创伤性脑损伤中的小胶质细胞全貌：2000-2023 年期间的文献计量分析和可视化研究。","authors":"Yuhang Zhang, Tingzhen Deng, Xiao Ding, Xingyuan Ma, Yatao Wang, Haijun Yang, Ruiwen Ding, Dawen Wang, Haotian Li, Maohua Zheng","doi":"10.3389/fncel.2024.1495542","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Traumatic brain injury (TBI) is a critical global health concern characterized by elevated rates of both morbidity and mortality. The pathological and physiological changes after TBI are closely related to microglia. Microglia, the primary immune cells in the brain, are closely linked to the mechanisms and treatment of TBI. With increasing research in this area, this study employs bibliometric analysis to identify current research hotspots and predict future trends.</p><p><strong>Objective: </strong>We decided to perform a bibliometric analysis to provide a comprehensive overview of the advancements in microglia research related to traumatic brain injury. We aim to offer researchers insights into current trends and future research directions.</p><p><strong>Method: </strong>We collected all articles and reviews related to microglia and traumatic brain injury published between 2000 and 2023 from the Web of Science Core Collection. These records were analyzed using VOSviewer, CiteSpace, and the R package \"bibliometrix\".</p><p><strong>Results: </strong>We retrieved 665 publications from 25 countries, with the majority contributed by the United States and China. The number of publications on traumatic brain injury and microglia has been steadily increasing each year. Our analysis highlighted the <i>Journal of Neurotrauma</i> and the <i>Journal of Neuroinflammation</i> as the most influential journals in this field. Alan I. Faden and David J. Loane are recognized as leading contributors. Keyword analysis indicates that neuroinflammation, microglial polarization, and neurodegenerative diseases are pivotal areas for future research.</p><p><strong>Conclusion: </strong>In recent years, research on TBI-related microglia has proliferated, with current studies primarily focusing on microglial involvement in neuroinflammation, neurodegenerative changes, and microglial polarization following TBI. Since neuroinflammation and neurodegeneration are two hallmark features of TBI, targeting microglia in TBI treatment may become a central focus for future research.</p>","PeriodicalId":12432,"journal":{"name":"Frontiers in Cellular Neuroscience","volume":"18 ","pages":"1495542"},"PeriodicalIF":4.2000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11578739/pdf/","citationCount":"0","resultStr":"{\"title\":\"Panaroma of microglia in traumatic brain injury: a bibliometric analysis and visualization study during 2000-2023.\",\"authors\":\"Yuhang Zhang, Tingzhen Deng, Xiao Ding, Xingyuan Ma, Yatao Wang, Haijun Yang, Ruiwen Ding, Dawen Wang, Haotian Li, Maohua Zheng\",\"doi\":\"10.3389/fncel.2024.1495542\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Traumatic brain injury (TBI) is a critical global health concern characterized by elevated rates of both morbidity and mortality. The pathological and physiological changes after TBI are closely related to microglia. Microglia, the primary immune cells in the brain, are closely linked to the mechanisms and treatment of TBI. With increasing research in this area, this study employs bibliometric analysis to identify current research hotspots and predict future trends.</p><p><strong>Objective: </strong>We decided to perform a bibliometric analysis to provide a comprehensive overview of the advancements in microglia research related to traumatic brain injury. We aim to offer researchers insights into current trends and future research directions.</p><p><strong>Method: </strong>We collected all articles and reviews related to microglia and traumatic brain injury published between 2000 and 2023 from the Web of Science Core Collection. These records were analyzed using VOSviewer, CiteSpace, and the R package \\\"bibliometrix\\\".</p><p><strong>Results: </strong>We retrieved 665 publications from 25 countries, with the majority contributed by the United States and China. The number of publications on traumatic brain injury and microglia has been steadily increasing each year. Our analysis highlighted the <i>Journal of Neurotrauma</i> and the <i>Journal of Neuroinflammation</i> as the most influential journals in this field. Alan I. Faden and David J. Loane are recognized as leading contributors. Keyword analysis indicates that neuroinflammation, microglial polarization, and neurodegenerative diseases are pivotal areas for future research.</p><p><strong>Conclusion: </strong>In recent years, research on TBI-related microglia has proliferated, with current studies primarily focusing on microglial involvement in neuroinflammation, neurodegenerative changes, and microglial polarization following TBI. Since neuroinflammation and neurodegeneration are two hallmark features of TBI, targeting microglia in TBI treatment may become a central focus for future research.</p>\",\"PeriodicalId\":12432,\"journal\":{\"name\":\"Frontiers in Cellular Neuroscience\",\"volume\":\"18 \",\"pages\":\"1495542\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2024-11-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11578739/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Cellular Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fncel.2024.1495542\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Cellular Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fncel.2024.1495542","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
背景：创伤性脑损伤（TBI）是一个严重的全球健康问题，其特点是发病率和死亡率都很高。创伤性脑损伤后的病理和生理变化与小胶质细胞密切相关。小胶质细胞是大脑中的主要免疫细胞，与 TBI 的机制和治疗密切相关。随着该领域研究的不断深入，本研究采用文献计量分析法确定当前研究热点并预测未来趋势：我们决定进行文献计量分析，全面概述与创伤性脑损伤相关的小胶质细胞研究进展。我们旨在为研究人员提供有关当前趋势和未来研究方向的见解：我们从科学网核心数据库中收集了 2000 年至 2023 年间发表的所有与小胶质细胞和创伤性脑损伤相关的文章和综述。我们使用 VOSviewer、CiteSpace 和 R 软件包 "bibliometrix "对这些记录进行了分析：我们检索到来自 25 个国家的 665 篇论文，其中大部分来自美国和中国。有关创伤性脑损伤和小胶质细胞的论文数量每年都在稳步增长。我们的分析显示，《神经创伤杂志》（Journal of Neurotrauma）和《神经炎症杂志》（Journal of Neuroinflammation）是该领域最有影响力的杂志。Alan I. Faden 和 David J. Loane 是公认的主要撰稿人。关键词分析表明，神经炎症、小胶质细胞极化和神经退行性疾病是未来研究的关键领域：近年来，有关创伤性脑损伤相关小胶质细胞的研究激增，目前的研究主要集中在创伤性脑损伤后小胶质细胞参与神经炎症、神经退行性变化和小胶质细胞极化。由于神经炎症和神经退行性变是创伤性脑损伤的两个标志性特征，因此在创伤性脑损伤治疗中以小胶质细胞为靶点可能成为未来研究的核心重点。
Panaroma of microglia in traumatic brain injury: a bibliometric analysis and visualization study during 2000-2023.
Background: Traumatic brain injury (TBI) is a critical global health concern characterized by elevated rates of both morbidity and mortality. The pathological and physiological changes after TBI are closely related to microglia. Microglia, the primary immune cells in the brain, are closely linked to the mechanisms and treatment of TBI. With increasing research in this area, this study employs bibliometric analysis to identify current research hotspots and predict future trends.
Objective: We decided to perform a bibliometric analysis to provide a comprehensive overview of the advancements in microglia research related to traumatic brain injury. We aim to offer researchers insights into current trends and future research directions.
Method: We collected all articles and reviews related to microglia and traumatic brain injury published between 2000 and 2023 from the Web of Science Core Collection. These records were analyzed using VOSviewer, CiteSpace, and the R package "bibliometrix".
Results: We retrieved 665 publications from 25 countries, with the majority contributed by the United States and China. The number of publications on traumatic brain injury and microglia has been steadily increasing each year. Our analysis highlighted the Journal of Neurotrauma and the Journal of Neuroinflammation as the most influential journals in this field. Alan I. Faden and David J. Loane are recognized as leading contributors. Keyword analysis indicates that neuroinflammation, microglial polarization, and neurodegenerative diseases are pivotal areas for future research.
Conclusion: In recent years, research on TBI-related microglia has proliferated, with current studies primarily focusing on microglial involvement in neuroinflammation, neurodegenerative changes, and microglial polarization following TBI. Since neuroinflammation and neurodegeneration are two hallmark features of TBI, targeting microglia in TBI treatment may become a central focus for future research.
期刊介绍：
Frontiers in Cellular Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the cellular mechanisms underlying cell function in the nervous system across all species. Specialty Chief Editors Egidio D‘Angelo at the University of Pavia and Christian Hansel at the University of Chicago are supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
