治疗糖尿病：iPSC 和源自 ESC 的胰岛细胞移植试验。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-11-22 DOI:10.1111/jdi.14366

Junji Fujikura, Takayuki Anazawa, Taro Toyoda, Ryo Ito, Yasuko Kimura, Daisuke Yabe

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引用次数: 0

摘要

再生医学的进步，尤其是通过使用诱导多能干细胞（iPSC）和胚胎干细胞（ESC）取得的进步，正引起人们的广泛关注，因为它们是解决供体有限问题的潜在方案，而供体有限会导致需要移植已故供体胰岛细胞的1型糖尿病患者的等待时间延长。近期临床试验的良好结果表明，移植 iPSC 或 ESC 衍生的胰岛细胞可为更有效、更广泛的治疗方案铺平道路。这一进展不仅对1型糖尿病患者具有潜力，未来还可能扩展到2型糖尿病的治疗。

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Toward a cure for diabetes: iPSC and ESC-derived islet cell transplantation trials.

Advancements in regenerative medicine, particularly through the use of induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), are garnering substantial attention as potential solutions to the limited availability of donors, leading to prolonged waiting periods for people with type 1 diabetes who require transplantation of pancreatic islets from deceased donors. The promising outcomes from recent clinical trials suggest that transplantation of iPSC- or ESC-derived islet cells could pave the way for more effective and broadly accessible treatment options. This progress holds potential not only for individuals with type 1 diabetes but may also extend to type 2 diabetes treatment in the future.

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).