作为普通人群胰岛素抵抗、肝酶和代谢功能障碍相关脂肪性肝病生物标志物的肝素白细胞衍生趋化因子 2。

IF 3.2 3区 医学
Keita Suzuki, Hiromasa Tsujiguchi, Akinori Hara, Yumie Takeshita, Hisanori Goto, Yujiro Nakano, Reina Yamamoto, Hiroaki Takayama, Atsushi Tajima, Tatsuya Yamashita, Masao Honda, Hiroyuki Nakamura, Toshinari Takamura
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引用次数: 0

摘要

目的/简介:白细胞衍生趋化因子2(LECT2)是一种与肥胖相关的肝脏因子,可导致骨骼肌胰岛素抵抗。由于 LECT2 会因肝脏中能量传感器 AMPK 的失活而上调,我们推测 LECT2 有可能成为代谢功能障碍相关性脂肪性肝病(MASLD)的生物标志物。因此,我们研究了循环 LECT2 水平是否与胰岛素敏感性、肝酶和 MASLD 相关:这项横断面研究包括 138 名日本人。采用空腹血样测量血浆 LECT2 水平。采用 B 型超声波检查评估肝脏脂肪变性:结果:参与者的平均年龄和体重指数(BMI)分别为 63.5 ± 10.2 岁和 23.0 ± 3.1 kg/m2。在所有参与者中,较高的 LECT2 水平与胰岛素抵抗静态模型评估(HOMA-IR)值呈正相关,而与胰岛素敏感性定量检查指数(QUICKI)呈负相关(HOMA-IR;非标准化 β (B) = 6.38,P 结论:本研究结果表明,血浆中 LECT2 水平与胰岛素抵抗静态模型评估(HOMA-IR)值呈正相关,而与胰岛素敏感性定量检查指数(QUICKI)呈负相关:本研究结果表明,血浆 LECT2 水平有可能成为非超重人群胰岛素抵抗的生物标志物,也表明了 MASLD 在普通人群中的流行程度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hepatokine leukocyte cell-derived chemotaxin 2 as a biomarker of insulin resistance, liver enzymes, and metabolic dysfunction-associated steatotic liver disease in the general population.

Aims/introduction: Leukocyte cell-derived chemotaxin 2 (LECT2) is an obesity-associated hepatokine that causes skeletal muscle insulin resistance. Since LECT2 is up-regulated by the inactivation of the energy sensor AMPK in the liver, we hypothesized that LECT2 has potential as a biomarker for metabolic dysfunction-associated steatotic liver disease (MASLD). Therefore, we investigated whether circulating LECT2 levels are associated with insulin sensitivity, liver enzymes, and MASLD.

Materials and methods: This cross-sectional study included 138 Japanese individuals. Plasma LECT2 levels were measured using fasting blood samples. B-mode ultrasonography was used to assess hepatic steatosis.

Results: The mean age and body mass index (BMI) of participants were 63.5 ± 10.2 years and 23.0 ± 3.1 kg/m2, respectively. Higher LECT2 levels positively correlated with homeostatic model assessment for insulin resistance (HOMA-IR) values and negatively correlated with the quantitative insulin sensitivity check index (QUICKI) among all participants (HOMA-IR; non-standardized β (B) = 6.38, P < 0.01: QUICKI; B = -161, P < 0.01). These correlations were stronger in the low BMI group (HOMA-IR; B = 13.85, P < 0.01: QUICKI; B = -180, P < 0.01). LECT2 levels also positively correlated with gamma-glutamyl transferase levels (B = 0.01, P = 0.01) and alanine aminotransferase levels (B = 0.33, P = 0.02). Higher LECT2 levels correlated with the prevalence of MASLD (odds ratio = 1.14, P = 0.02).

Conclusions: The present results suggest the potential of plasma LECT2 levels as a biomarker for insulin resistance in individuals who are not overweight and the prevalence of MASLD in the general population.

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来源期刊
Journal of Diabetes Investigation
Journal of Diabetes Investigation Medicine-Internal Medicine
自引率
9.40%
发文量
218
期刊介绍: Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).
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