ACBP 协调库欣综合征的代谢表型

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2024-11-22 DOI:10.1038/s42255-024-01169-7

Mhairi Paul, Mark Nixon

引用次数: 0

摘要

库欣综合征是一种糖皮质激素长期过量的病症，会破坏代谢平衡，导致脂肪重新分布并促进胰岛素抵抗。新研究采用一系列优雅的方法揭示了酰基-CoA结合蛋白（ACBP）是小鼠糖皮质激素水平升高引起代谢紊乱的介质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

ACBP orchestrates the metabolic phenotype in Cushing’s syndrome

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ACBP orchestrates the metabolic phenotype in Cushing’s syndrome

Cushing’s syndrome, a condition of chronic glucocorticoid excess, disrupts metabolic homeostasis, driving fat redistribution and promoting insulin resistance. New research uses a series of elegant approaches to reveal acyl-CoA-binding protein (ACBP) as a mediator of the metabolic disturbances associated with elevated glucocorticoid levels in mice.

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.