Tsz Tung Kwong, Hao Hao Deng, Chi-Hang Wong, Anthony W H Chan, Landon Long Chan, Siu-Ho K Chok, Paul N Cheng, Stephen Chan
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PEG-BCT-100 and Canavanine Synergistically Induce Apoptosis in Arginine Biosynthetic Enzyme-Deficient Pancreatic Cancer.
Significance: This study investigates the synergistic antitumor effect of PEG-BCT-100, an arginase, in clinical trials, with canavanine in pancreatic cancer, in vitro and in vivo. The treatment induces cancer cell apoptosis while sparing normal fibroblasts. Our findings suggest heightened susceptibility of pancreatic tumors deficient in arginine biosynthesis enzymes ASS1 and OTC.
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