与口服利奈唑胺相关的严重乳酸酸中毒。

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL
Anya Ertmann, Rachael E Thompson, Zhe Hui Hoo, Frank P Edenborough
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引用次数: 0

摘要

我们介绍了一例因肺部脓肿分枝杆菌感染而长期口服利奈唑胺治疗的囊性纤维化患者,该患者出现了严重的利奈唑胺诱发乳酸酸中毒(LILA),导致凝血功能紊乱和全血细胞减少。乳酸酸中毒对静脉输液治疗产生了耐药性,但在开始持续静脉血液滤过后 20 小时内得到缓解。血液滤过的一个意外后果是,血管通路干扰了有效的胸部物理治疗,导致肺部合并症恶化,需要长时间静脉注射抗生素治疗并存的铜绿假单胞菌感染。鉴于 LILA 潜在的死亡率和发病率,监测乳酸水平可能具有重要的临床意义,但目前尚不清楚监测的最佳时机。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Severe lactic acidosis associated with oral linezolid.

We present the case of a patient with cystic fibrosis on long-term oral linezolid treatment for Mycobacteria abscessus lung infection who developed severe linezolid-induced lactic acidosis (LILA) resulting in deranged clotting and pancytopenia. The lactic acidosis was resistant to treatment with intravenous fluid but resolved within 20 hours of initiating continuous veno-venous haemofiltration. An unintended consequence of haemofiltration was that vascular access interfered with effective chest physiotherapy, resulting in worsened lung consolidation requiring prolonged intravenous antibiotic therapy for coexisting Pseudomonas aeruginosa infection. Given the potential mortality and morbidity of LILA, monitoring lactate levels may be clinically important but the optimum timing of monitoring is currently unclear.

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来源期刊
BMJ Case Reports
BMJ Case Reports Medicine-Medicine (all)
CiteScore
1.40
自引率
0.00%
发文量
1588
期刊介绍: BMJ Case Reports is an important educational resource offering a high volume of cases in all disciplines so that healthcare professionals, researchers and others can easily find clinically important information on common and rare conditions. All articles are peer reviewed and copy edited before publication. BMJ Case Reports is not an edition or supplement of the BMJ.
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