Austin G Kazarian, Raj R Bhanvadia, Zine-Eddine Khene, Thomas Gerald, Bailey Brooks, Yair Lotan, Isamu Tachibana, Kris Gaston, Sol Woldu, Vitaly Margulis
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Landscape of Genomic Profiling and Circulating Tumor DNA Among Rare Genitourinary Cancers
•
Current surveillance and treatment strategies of rare genitourinary cancers are heterogenous and often rely on classical imaging alone leaving opportunity for enhanced surveillance and treatment direction strategies.
•
Molecular residual disease assessment may offer many benefits to standard modalities including antecedent prediction of recurrence or progression compared to conventional surveillance, early and appropriate identification of patients appropriate for adjuvant treatment, potential for monitoring of treatment response, and adjudication of indeterminate imaging findings.
•
Comprehensive genomic profiling delineates tumor biology and actionable mutations for personalized medicine in this challenging to treat population including nonclassical targeted agents.
期刊介绍:
Clinical Genitourinary Cancer is a peer-reviewed journal that publishes original articles describing various aspects of clinical and translational research in genitourinary cancers. Clinical Genitourinary Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of genitourinary cancers. The main emphasis is on recent scientific developments in all areas related to genitourinary malignancies. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.