Pipelined information flow in molecular mechanical circuits leads to increased error and irreversibility.

Pipelining is a design technique for logical circuits that allows for higher throughput than circuits in which multiple computations are fed through the system one after the other. It allows for much faster computation than architectures in which inputs must pass through every layer of the circuit before the next computation can begin (phased chaining). We explore the hypothesis that these advantages may be offset by a higher error rate, logical irreversibility, and greater thermodynamic costs by simulating pipelined molecular mechanical circuits using an explicit physical model. We observe the emergent logical irreversibility, and see that the simultaneous action of multiple components indeed leads to a higher error rate than in phase-chained circuits. The thermodynamic costs of operating the gates are much larger than in equivalent phase-chained circuits, and these costs do not appear to tend to zero in the limit of slowgate operation. Redesigning the gates to eliminate errors and artificially enforcing logical reversibility reduces the thermodynamic costs and recovers thermodynamically reversible behavior in the limit of slow gate operation. The breakdown of logical reversibility and accuracy are both associated with a breakdown of the digital behavior of the device, likely contributing to thermodynamic costs that are large relative to the scale of the information being processed.