莱奈唑胺诱发致命性乳酸酸中毒和全血细胞减少症的病例

Q3 Medicine

The Journal of the Association of Physicians of India Pub Date : 2024-11-01 DOI:10.59556/japi.72.0735

Kundan Mehta, Rhea Gandhi, Islahuzzama Salahuddin Ansari, M S Barthwal

{"title":"莱奈唑胺诱发致命性乳酸酸中毒和全血细胞减少症的病例","authors":"Kundan Mehta, Rhea Gandhi, Islahuzzama Salahuddin Ansari, M S Barthwal","doi":"10.59556/japi.72.0735","DOIUrl":null,"url":null,"abstract":"We present a case of a 77-year-old female diagnosed with multidrug-resistant (MDR) pulmonary tuberculosis (PTB), on all oral longer regimen [according to Indian Programmatic Management of Drug Resistant Tuberculosis (PMDT) guidelines] for a month. She presented with nausea, vomiting, worsening of breathlessness for a week, pancytopenia, and gradually increasing lactate levels. Various causes of lactic acidosis including metabolic, septic, and hypoxic were ruled out. Despite our dedicated efforts, she tragically passed away due to severe lactic acidosis, a complication associated with linezolid treatment.","PeriodicalId":22693,"journal":{"name":"The Journal of the Association of Physicians of India","volume":"72 11","pages":"e45-e46"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Case Involving Linezolid-induced Fatal Lactic Acidosis and Pancytopenia.\",\"authors\":\"Kundan Mehta, Rhea Gandhi, Islahuzzama Salahuddin Ansari, M S Barthwal\",\"doi\":\"10.59556/japi.72.0735\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We present a case of a 77-year-old female diagnosed with multidrug-resistant (MDR) pulmonary tuberculosis (PTB), on all oral longer regimen [according to Indian Programmatic Management of Drug Resistant Tuberculosis (PMDT) guidelines] for a month. She presented with nausea, vomiting, worsening of breathlessness for a week, pancytopenia, and gradually increasing lactate levels. Various causes of lactic acidosis including metabolic, septic, and hypoxic were ruled out. Despite our dedicated efforts, she tragically passed away due to severe lactic acidosis, a complication associated with linezolid treatment.\",\"PeriodicalId\":22693,\"journal\":{\"name\":\"The Journal of the Association of Physicians of India\",\"volume\":\"72 11\",\"pages\":\"e45-e46\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of the Association of Physicians of India\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.59556/japi.72.0735\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of the Association of Physicians of India","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.59556/japi.72.0735","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

我们报告了一例 77 岁女性患者的病例，她被诊断患有耐多药（MDR）肺结核（PTB），一个月来一直在口服长效治疗方案（根据印度耐药结核病方案管理指南（PMDT））。她出现恶心、呕吐、呼吸困难加重一周、全血细胞减少以及乳酸水平逐渐升高。我们排除了导致乳酸酸中毒的各种原因，包括代谢性、败血症和缺氧。尽管我们竭尽全力，但她还是因利奈唑胺治疗引起的并发症--严重乳酸酸中毒而不幸去世。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

A Case Involving Linezolid-induced Fatal Lactic Acidosis and Pancytopenia.

We present a case of a 77-year-old female diagnosed with multidrug-resistant (MDR) pulmonary tuberculosis (PTB), on all oral longer regimen [according to Indian Programmatic Management of Drug Resistant Tuberculosis (PMDT) guidelines] for a month. She presented with nausea, vomiting, worsening of breathlessness for a week, pancytopenia, and gradually increasing lactate levels. Various causes of lactic acidosis including metabolic, septic, and hypoxic were ruled out. Despite our dedicated efforts, she tragically passed away due to severe lactic acidosis, a complication associated with linezolid treatment.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

The Journal of the Association of Physicians of India Medicine-Medicine (all)

CiteScore

0.80

自引率

0.00%

发文量

509