消化系统癌症中涉及 ncRNA 的表观遗传修饰：关注组蛋白修饰。

IF 4.8 2区医学 Q1 GENETICS & HEREDITY

Clinical Epigenetics Pub Date : 2024-11-19 DOI:10.1186/s13148-024-01773-0

Xiaodi Yin, Jingyi Li, Jiahui Zhao, Weihan Zheng, Aohua Zhang, Jun Ma

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引用次数: 0

摘要

近年来，表观遗传修饰与肿瘤的发生发展密切相关，其中组蛋白修饰是一种关键的表观遗传机制。此外，非编码 RNA（ncRNA）在调控癌症相关通路方面也发挥着关键作用。组蛋白修饰和 ncRNAs 都是关键的表观遗传调控因子，它们之间的异常相互作用已在各种癌症类型中被广泛观察到。在这里，我们系统地探讨了组蛋白修饰和 ncRNA 在消化系统癌症发病机制中的作用，以及 ncRNA 介导的异常组蛋白修饰操纵肿瘤细胞增殖、迁移、血管生成等各种生物学行为的分子机制。此外，我们还从表观遗传学的角度为消化系统癌症的诊断、预后标志物、治疗靶点和化疗耐药性提供了新的见解。

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Epigenetic modifications involving ncRNAs in digestive system cancers: focus on histone modification.

In recent years, epigenetic modifications have been strongly linked to tumor development, with histone modifications representing a key epigenetic mechanism. In addition, non-coding RNAs (ncRNAs) play a critical role in regulating cancer-related pathways. The abnormal interaction between histone modifications and ncRNAs, both pivotal epigenetic regulators, has been widely observed across various cancer types. Here, we systematically explore the molecular mechanisms through which histone modifications and ncRNAs contribute in the pathogenesis of digestive system cancers, and aberrant ncRNA-mediated histone modifications manipulate various biological behaviors of tumor cells including proliferation, migration, angiogenesis, etc. In addition, we provide new insights into diagnostic, prognostic markers, therapeutic targets and chemoradiation resistance for digestive system cancers from the epigenetic perspective.

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来源期刊

Clinical Epigenetics ONCOLOGY-

自引率

5.30%

发文量

150

期刊介绍： Clinical Epigenetics, the official journal of the Clinical Epigenetics Society, is an open access, peer-reviewed journal that encompasses all aspects of epigenetic principles and mechanisms in relation to human disease, diagnosis and therapy. Clinical trials and research in disease model organisms are particularly welcome.